Structure–phototoxicity relationship in Balb/c mice treated with fluoroquinolone derivatives, followed by ultraviolet-A irradiation

A Dermal Phototoxicity Study Following Intravenous Infusion Administration of Ciprofloxacin Hydrochloride in the Novel Microminipigs

“…Similar histopathological lesions, such as cellular infiltration in the auricle, had been observed in mice that received a single intravenous administration of 100 mg/kg ciprofloxacin at 96 hr after irradiation (Yabe et al 2005). To our knowledge, time-dependent histopathological examinations of other experimental animals have not been conducted and vesicle formation in the subepidermis has not been reported.…”

“…CPFX (Wako Pure Chemical Industries, Ltd., Osaka, Japan) was diluted to 20 mg/mL in physiological saline. CPFX 100 mg/kg was set as the dose level expected to induce phototoxicity, as previously reported in mice (Yabe et al 2005).…”

Design, synthesis and biological evaluations of novel 7-[3-(1-aminocycloalkyl)pyrrolidin-1-yl]-6-desfluoro-8-methoxyquinolones with potent antibacterial activity against multi-drug resistant Gram-positive bacteria

“…Thus, compound 5 showed a positive response, even though it has a combination of des-F(6) and the (1R,2S)-2-fluorocyclopropan-1-yl group at the N-1 position, which are reported to reduce genotoxicity. [23][24][25][26][27][28] The des-F(6) compounds 4, 6 and 8 showed negative responses as we expected. The results indicate the advantage of removing the fluorine atom at the C-6 position for reducing intravenous single-dose toxicity and micronuclei-forming toxicity.…”

Tyrosine Kinase Inhibitors Enhance Ciprofloxacin-Induced Phototoxicity by Inhibiting ABCG2

“…The goal of this study was to determine if pharmacological inhibition of ABCG2 would enhance fluoroquinolone-induced phototoxicity using a cell culture system. Ciprofloxacin was selected as a representative fluoroquinolone with intermediate phototoxic potential [12]. …”