Structure-oriented engineering of nitrile hydratase: Reshaping of substrate access tunnel and binding pocket for efficient synthesis of cinnamamide

Amorphous Fe0.7Cu0.3Ox as a Bifunctional Catalyst for Selective Hydration of Nitriles to Amides in Water

“…5 Cinnamamide exhibits significant pharmacological potential in treating a range of diseases, from tumors to cardiovascular ailments. 6,7 Additionally, niacinamide, a vital B vitamin, and pyrazinamide, an antituberculosis agent, underscore the versatility of amides in pharmaceutical applications. 8 Moreover, the antitumor properties of various thiophene and furan amide derivatives have also been reported.…”

“…Amide groups play a pivotal role as fundamental structural units in peptides, enzymes, and proteins, making amides crucial in diverse sectors including medicine, agriculture, and chemical industries. − For instance (Figure ), acrylamide is essential for producing polyacrylamide, which is widely used in water treatment and various industrial processes . Cinnamamide exhibits significant pharmacological potential in treating a range of diseases, from tumors to cardiovascular ailments. , Additionally, niacinamide, a vital B vitamin, and pyrazinamide, an antituberculosis agent, underscore the versatility of amides in pharmaceutical applications . Moreover, the antitumor properties of various thiophene and furan amide derivatives have also been reported .…”