Structure of Toll-Like Receptors, Signal Transduction, and Regulation

Wang, Jian; Cao, Weiya; Cai, Wenjie; Li, Cun-Di; Sun, Lin

doi:10.1166/nnl.2017.2374

Cited by 4 publications

(3 citation statements)

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“…Meanwhile, the trapped virus also allows multi‐parameter analysis of single virions, such as heterogeneity in transmission and infection. [ 34 ] Viruses can also be quantified by observing the accumulated signals from multiple viruses trapped. The ring resonator is another alternative configuration that stores light in the whispering gallery mode (WGM) with a high quality factor (up to 10 6 ).…”

Section: On‐chip Optical Methodsmentioning

confidence: 99%

“…Pang et al reported that the trapping of individual HIV‐1 viruses allowed the multi‐parameter analysis of single virions in culture fluid environmentally mimicking native conditions (Figure 5b). [ 34,101 ] It was shown that individual HIV‐1 differed in the number of envelope glycoproteins by over one order of magnitude, indicating substantial heterogeneities of viral particles in transmission and infection at the single‐virus level. Using the plasmonic nanohole array in an optofluidic chip, Yanik et al reported a fast and label‐free virus‐detecting chip utilizing group‐specific antibodies targeting highly divergent strains of rapidly evolving viruses (Figure 5c).…”

Section: Optofluidic Detection Of Virusmentioning

confidence: 99%

Section: Optofluidic Detection Of Virusmentioning

confidence: 99%

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On‐Chip Optical Detection of Viruses: A Review

Shi

Liu

et al. 2021

Advanced Photonics Research

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The current outbreak of the coronavirus disease‐19 (COVID‐19) pandemic worldwide has caused millions of fatalities and imposed a severe impact on our daily lives. Thus, the global healthcare system urgently calls for rapid, affordable, and reliable detection toolkits. Although the gold‐standard nucleic acid amplification tests have been widely accepted and utilized, they are time‐consuming and labor‐intensive, which exceedingly hinder the mass detection in low‐income populations, especially in developing countries. Recently, due to the blooming development of photonics, various optical chips have been developed to detect single viruses with the advantages of fast, label‐free, affordable, and point of care deployment. Herein, optical approaches especially in three perspectives, e.g., flow‐free optical methods, optofluidics, and surface‐modification‐assisted approaches, are summarized. The future development of on‐chip optical‐detection methods in the wave of emerging new ideas in nanophotonics is also briefly discussed.

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Section: On‐chip Optical Methodsmentioning

confidence: 99%

Section: Optofluidic Detection Of Virusmentioning

confidence: 99%