Structure of the L-histidine decarboxylase gene.

Yatsunami, Kimio; Ohtsu, Hiroshi; Tsuchikawa, M.; Higuchi, Takahide; Ishibashi, Kazuko; Shida, Atsuhiko; Shima, Yasufumi; Nakagawa, Satoshi; Yamauchi, Kohei; Yamamoto, Masayuki

doi:10.1016/s0021-9258(17)42292-7

Cited by 58 publications

(6 citation statements)

References 35 publications

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“…While the relationship between the expression of MC-CPA activated by GATA-1 and differentiation of mast cells is suspected, it has been reported that the level of MC-CPA mRNA increases upon treatment with dexamethasone, a synthetic glucocorticoid, in mBMMC (Eklund et al, 1997). There is an evidence that four GATA consensus sequences are present in the promoter region of the human HDC gene (Yatsunami et al, 1994). It has been recently shown that GATA-1 binds to enhancers of human FcεRIα-chain gene (Nishiyama et al, 1999).…”

Section: Discussionmentioning

confidence: 99%

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2000

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Hydrocortisone was investigated for its ability todifferentiate human leukemia KU812 cells into maturehematopoietic cells including basophils. Hydrocortisonetreatment increased the amount of intracellular histamine byup-regulation of L-histidine decarboxylase (HDC) mRNA andenhanced cell surface expression of the high affinity IgEreceptor FcepsilonRI. Histamine is catalyzed from L-histidine byHDC, which in blood cell types is only expressed in basophilsand mast cells. Cells, on which the FcepsilonRI expression wasenhanced by hydrocortisone, were shown to release histaminewhen stimulated with anti-IgE antibody after sensitizationwith myeloma IgE, implying that the induced FcepsilonRI moleculeswere able to transduce a signal for degranulation. Theseresults suggest that hydrocortisone promotes differentiationof KU812 cells into functionally mature basophilic cells.

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Section: Discussionmentioning

confidence: 99%

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2000

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“…Histamine synthesis rate depends on the HDC expression regulation, a process which seems to have a strong cell-specific component. Yatsunami et al [42] located promoter fragments involved in HDC induction by TPA plus dexamethasone and cAMP plus Ca 2+ in basophilic cells. HDC regulation in basophilic cells seems to involve several cis-elements such as a TATA-like sequence, a GC box, four CACC boxes, four GATA sequences and 6 leader-binding protein-1 binding motifs, as well as a c-Myb motif, and other positive and negative motifs located in the promoter between positions -497 and -855 in the gene.…”

Section: Histamine Metabolism and Its Connections To Other Metabolic Modulesmentioning

confidence: 99%

Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach

et al. 2021

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Histamine is a highly pleiotropic biogenic amine involved in key physiological processes including neurotransmission, immune response, nutrition, and cell growth and differentiation. Its effects, sometimes contradictory, are mediated by at least four different G-protein coupled receptors, which expression and signalling pathways are tissue-specific. Histamine metabolism conforms a very complex network that connect many metabolic processes important for homeostasis, including nitrogen and energy metabolism. This review brings together and analyses the current information on the relationships of the “histamine system” with other important metabolic modules in human physiology, aiming to bridge current information gaps. In this regard, the molecular characterization of the role of histamine in the modulation of angiogenesis-mediated processes, such as cancer, makes a promising research field for future biomedical advances.

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“…One such study investigated the functional analysis of two HDC cDNA clones representing the 3.4-and 2.4-kb HDC transcripts of a human basophilic cell line (KU-812-F). It was determined that the 3.4-kb mRNA is an alternately spliced transcript in which the 7th intron (824 bp) is not spliced out and contains an in-frame translation stop codon resulting in a truncated protein, whereas the 2.4-kb mRNA was found to encode a functional HDC enzyme (14,27). Likewise, it was demonstrated in COS cells that the 2.6-kb HDC mRNA, isolated from rat fetal liver, encodes a functional HDC (10).…”

Section: L409mentioning

confidence: 99%

Glucocorticoid hormones downregulate histidine decarboxylase mRNA and enzyme activity in rat lung

Zahnow

Panula

Yamatodani

et al. 1998

American Journal of Physiology-Lung Cellular and Molecular Phys

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Histidine decarboxylase (HDC) is the primary enzyme regulating histamine biosynthesis. Histamine contributes to the pathogenesis of chronic inflammatory disorders such as asthma. Because glucocorticoids are effective in the treatment of asthma, we examined the effects of 6 h of exogenously administered dexamethasone (0.5–3,000 μg/kg ip), corticosterone (0.2–200 mg/kg ip), or endogenously elevated corticosterone (via exposure of rats to 10% oxygen) on HDC expression in the rat lung. HDC transcripts were decreased ∼73% with dexamethasone treatment, 57% with corticosterone treatment, and 50% with exposure to 10% oxygen. Likewise, HDC enzyme activity was decreased 80% by treatment with dexamethasone and corticosterone and 60% by exposure to 10% oxygen. Adrenalectomy prevented the decreases in HDC mRNA and enzyme activity observed in rats exposed to 10% oxygen, suggesting that the adrenal gland is necessary for the mediation of hypoxic effects on HDC gene expression. These results demonstrate that corticosteroids initiate a process that leads to the decrease of HDC mRNA levels and enzyme activity in rat lung.

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Structure of the L-histidine decarboxylase gene.

Cited by 58 publications

References 35 publications

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Histamine, Metabolic Remodelling and Angiogenesis: A Systems Level Approach

Glucocorticoid hormones downregulate histidine decarboxylase mRNA and enzyme activity in rat lung

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