Structure of the glycosides of Asparagus officinalis

Goryanu, G. M.; Krokhmalyuk, V. V.; Kintya, P. K.

doi:10.1007/bf00567829

Cited by 3 publications

(2 citation statements)

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“…A considerable number of chemical constituents including flavonoids (8), oligosaccharides (9), amino acid derivatives (10), sulfurcontaining acids (11), and steroidal saponins (12)(13)(14)(15) have been isolated from the roots and shoots. Saponins were shown to be the major components and suggested to be responsible for the biological properties of this plant.…”

Section: Introductionmentioning

confidence: 99%

Steroidal Saponins fromAsparagus officinalisand Their Cytotoxic Activity

et al. 1997

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Two oligofurostanosides were isolated from the seeds of Asparagus officinalis L and their structures characterized as 3-O-[alpha-L-rhamnopyranosyl-(1-->2)-(alpha-L-rhamnopyranosyl- (1-->4))-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-(25R) -22 alpha-methoxyfurost-5-ene-3 beta,26-diol(methyl protodioscin) and its corresponding 22 alpha-hydroxy analogue (protodioscin). The structural identification was performed using detailed analysis of 1H- and 13C-NMR spectra including two-dimensional NMR spectroscopy (COSY, HMQC, NOESY and HMBC), and chemical conversions. These two compounds have been shown to inhibit the growth of human leukemia HL-60 cells in culture and macromolecular synthesis in a dose-dependent manner. The inhibitory effect on DNA synthesis was found to be irreversible.

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Section: Introductionmentioning

confidence: 99%

Steroidal Saponins fromAsparagus officinalisand Their Cytotoxic Activity

et al. 1997

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“…SeveralAsparagus species are known for their medicinal uses [1]. Various furostanol glycosides have been reported [2][3][4][5][6][7][8][9] from different parts of these plants. A survey of the literature showed that no chemical work has been done on the plant Asparagus Curillus.…”

Section: Introductionmentioning

confidence: 99%