Structure of polymer and particle aggregates in hydrogel composites

Berts, Ida; Gerelli, Yuri; Hilborn, Jöns; Rennie, Adrian R.

doi:10.1002/polb.23230

Cited by 15 publications

(10 citation statements)

References 47 publications

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“…The investigation of the composite HYH–HAP gel’s microstructure highlighted the influence of HYH particle size and shape and particle size distribution on the gel properties [ 22 , 40 ]. Other investigations showed that gel pore size, porosity, and swelling decreased with increasing HYH concentration [ 41 ].…”

Section: Hyh–hap and Hyh–cap Compositesmentioning

confidence: 99%

“…Due to its unique gel-forming properties, HYH has generated significant interest for the fabrication of composite gels. HYH hydrogels can function as a matrix to incorporate both organic and inorganic substances to enhance tissue growth [ 22 ]. HYH and composites showed interesting biomineralization properties, which are currently under intensive investigation for various applications [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

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Hyaluronic-Acid-Based Organic-Inorganic Composites for Biomedical Applications

2021

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Applications of natural hyaluronic acid (HYH) for the fabrication of organic–inorganic composites for biomedical applications are described. Such composites combine unique functional properties of HYH with functional properties of hydroxyapatite, various bioceramics, bioglass, biocements, metal nanoparticles, and quantum dots. Functional properties of advanced composite gels, scaffold materials, cements, particles, films, and coatings are described. Benefiting from the synergy of properties of HYH and inorganic components, advanced composites provide a platform for the development of new drug delivery materials. Many advanced properties of composites are attributed to the ability of HYH to promote biomineralization. Properties of HYH are a key factor for the development of colloidal and electrochemical methods for the fabrication of films and protective coatings for surface modification of biomedical implants and the development of advanced biosensors. Overcoming limitations of traditional materials, HYH is used as a biocompatible capping, dispersing, and structure-directing agent for the synthesis of functional inorganic materials and composites. Gel-forming properties of HYH enable a facile and straightforward approach to the fabrication of antimicrobial materials in different forms. Of particular interest are applications of HYH for the fabrication of biosensors. This review summarizes manufacturing strategies and mechanisms and outlines future trends in the development of functional biocomposites.

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Section: Hyh–hap and Hyh–cap Compositesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hyaluronic-Acid-Based Organic-Inorganic Composites for Biomedical Applications

2021

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“…The in-vitro gelling capacity was determined by placing test the freshly prepared solution 0.5 ml of in-situ about quantity timolol hydro which gel in a vial containing freshly prepared simulated tear fluid pH 7.4 and equilibrated at 37ºC. The with temperature visual assessment of gel inspection can also be done for the (Berts et al, 2013).…”

Section: Of Gelling Consistency Eterminationmentioning

confidence: 99%

Design, characterization and evaluation of hydrogel based Timolol formulation for effective treatment of Glaucoma

Lall¹

2020

Asian J Pharm Pharmacol

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Objective: An attempt has been made with the three dimensional structured hydrogel based formulation. Objective of the work to design, development and characterization of Timolol hydrogel formulation for Glaucoma with minimum dose of timolol about 0.1% achieved maximum therapeutics response with prolonged duration of application. Materials and methods: Material were used in this research work the raw drug of Timolol maleate, gellan gum, chitosan, PLGA and other materials of analytical grade used. Cold condensation method was used to prepare timolol hydrogel. Prepared hydrogel was characterized by different parameters like release pattern, viscosity, pH, permeation and sterility. Results were showed timolol maleate under hydrogel formulation possess much Results and conclusion: stable and increase in bioavailability with compare to its convectional dosage form. It was showed that hydrogel enhances the contact time into the eye after administering with prolonged duration of drug release from the formulation without possess any inflammation and side effects. Timolol maleate under hydrogel formulation comes with various advantageous over present formulation, it requires less dosage 0.1% of Timolol maleate in single administration, among present formulation in the marketed this attempt hydrogel formulation would be definitely beneficial with appropriate less dose uses with maximum therapeutic responses. Much stable with prolonged duration drug release can be achieved.

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“…The mechanism of NC in improving mechanical strength is similar to that of rubber reinforcing [21], i.e., by using the surface activity of carbon black particles to adsorb the molecular chains of rubber, forming similar physical crosslinkages so as to play a powerful role in reinforcement and greatly improve its mechanical properties. NCs, depending on the types of nanoparticles, can be divided into the following categories: clay composite hydrogels [22], polymer particle composite hydrogels [23], carbon nanotube reinforced polymer hydrogels [24], and crosslinked polyvinyl alcohol (PVA) nanofiber hydrogels [25].…”

Section: Polymeric Hydrogels With Mechanical Propertiesmentioning

confidence: 99%

Applications of Hydrogels with Special Physical Properties in Biomedicine

et al. 2019

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As a polymer matrix containing a large amount of water, hydrogels have been widely used in many fields such as biology and medicine due to its similarity to extracellular matrix components, and its contact with blood, body fluids, and human tissue does not affect the metabolic processes of living organisms. However, due to the lack of unique physical properties of traditional polymer hydrogels, its further application in the high-end field is limited. With the progress of study, a series of hydrogels with special structures, such as double network hydrogel, composite hydrogel, Tetra-PEG gel, and topological gel, have improved the situation to a large extent. At the same time, the progress of research on the biocompatibility and biodegradability of hydrogels, which are expected to be used in biomedical fields, is also worthy of attention. This review introduces four such types of high-strength polymeric hydrogels and the mechanisms for improving their mechanical strength. Moreover, a discussion will be made around specific methods for imparting special physical properties to hydrogels and applications in the field of biomedicine such as cell culture, medical surgery, tissue engineering, and biosensing. At the end of the review, the main reasons and contradictions for the limits of the current applications are explained. An outlook on the future research in related fields and the importance of carrying out research in this area to promote medical progress are emphasized.

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Structure of polymer and particle aggregates in hydrogel composites

Cited by 15 publications

References 47 publications

Hyaluronic-Acid-Based Organic-Inorganic Composites for Biomedical Applications

Hyaluronic-Acid-Based Organic-Inorganic Composites for Biomedical Applications

Design, characterization and evaluation of hydrogel based Timolol formulation for effective treatment of Glaucoma

Applications of Hydrogels with Special Physical Properties in Biomedicine

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