STRUCTURE OF MUKAADIAL, A MOLLUSCICIDE FROM THE <i>WARBURGIA</i> PLANTS

Kubo, Isao; Matsumoto, Takeshi; Kakooko, A B; Mubiru, Nasani K.

doi:10.1246/cl.1983.979

Cited by 37 publications

(24 citation statements)

References 2 publications

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“…glabrata [267] Curcumin Schistosoma mansoni adult worms [278,279] Asparagalin A Schistosoma mansoni adult worms [280] Piplartine IC 50 -5 mM Schistosomula [281] Trachoma Berberine Stimulates a protective mechanism in the host Patients with clinically active trachoma lesions [232] Biochanin A 12 mM Ch. glabrata [267] Curcumin Schistosoma mansoni adult worms [278,279] Asparagalin A Schistosoma mansoni adult worms [280] Piplartine IC 50 -5 mM Schistosomula [281] Trachoma Berberine Stimulates a protective mechanism in the host Patients with clinically active trachoma lesions [232] Biochanin A 12 mM Ch.…”

Section: Denguementioning

confidence: 99%

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From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)

Oliveira

Chiaradia-Delatorre²,

Mascarello³

et al. 2015

Studies in Natural Products Chemistry

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Section: Denguementioning

confidence: 99%

“…pfeifferi snails. The sesquiterpene warburganal was very active and killed Biomphalaria snails at 2 ppm within 24 hours [266,267]. glabrata snails at concentrations of 50 ppm [263].…”

Section: Schistosomiasismentioning

confidence: 99%

From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)

Oliveira

Chiaradia-Delatorre²,

Mascarello³

et al. 2015

Studies in Natural Products Chemistry

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“…Warburganal has shown effective molluscicidal activity . Warburgia stuhlmannii and W. ugandensis demonstrated molluscicidal activity (Kubo et al, 1983), making them potential in the control of schistosomiasis. Drimane sesquiterpenoids are known to have molluscicidal activity Fukuyama et al, 1982;Taniguchi & Kubo, 1993).…”

Section: Molluscicidal Activitymentioning

confidence: 99%

“…Warburgia salutaris, W. stuhlmannii and W. ugandensis have yielded a series of drimane sesquiterpenoids such as isopolygodial, muzigadial, polygodial, salutarisolide, ugandensidial and warburganal (Brooks & Draffan, 1969;Jansen & de Groot, 1991;Kioy et al, 1990;Kubo et al, , 1983Manguro et al, 2003;Mashimbye et al, 1999a;Rabe & van Staden, 2000;Wube et al, 2005;Xu et al, 2009). The genus certainly has a high use value.…”

Section: Introductionmentioning

confidence: 99%

The genusWarburgia: A review of its traditional uses and pharmacology

Maroyi

2013

Pharmaceutical Biology

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Context: Warburgia (Canellaceae) species have a long history of ethnomedicinal uses in east, central and southern Africa. Due to the popularity of Warburgia as a source of ethnomedicines; all the species are severely over-harvested throughout their distributional ranges. Objective: This review documents fragmented information on traditional uses and pharmacological evidence of the genus Warburgia. Methods: Information on Warburgia species was collected from scientific journals, books, theses and reports via library and electronic search using Medline, Pubmed, Google Scholar, ScienceDirect and Web of Science. Results: Ethnomedicinal uses of Warburgia species have been recorded from east, central and southern Africa for 30 human and 7 animal ailments. Warburgia species are used to treat gastrointestinal disorders, cold, cough and sore throat; fever or malaria, respiratory and odontological ailments. Warburgia species are rich in drimane and colorotane sesquiterpenoides, and other compounds. The extracts of Warburgia, particularly those from stem bark and leaves, exhibited a wide range of pharmacological effects, including antibacterial, antifungal, antimycobacterial, antioxidant, anti-inflammatory, antifeedant, antiplasmodial, antileishmanial, anthelmintic, cytotoxic and molluscicidal activities. Conclusion: Pharmacological results have validated the use of this genus in traditional medicine. Further investigations are needed to explore the bioactive compounds responsible for the in vitro and in vivo pharmacological effects and their mode of action.

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“…Various biological activities, including insect antifeedant, antimicrobial and antifungal (Kubo et al, 1983;Kubo and Taniguchi, 1988), were ascribed to Warburgia sesquiterpenes but there is no record on their antiprotozoal properties in spite of the extensive use of W. ugandensis in East African ethnomedicine for the treatment of malaria. Only two reports are available for the antiprotozoal potential of the extracts of this species.…”

Section: Introductionmentioning

confidence: 99%

Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro

Wube

Bučar

Gibbons

et al. 2010

Phytotherapy Research

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The extracts and 12 sesquiterpenes obtained from the East African medicinal plant Warburgia ugandensis Sprague (Canellaceae) were assessed for their antiplasmodial activity against the chloroquine-sensitive (3D7) and chloroquine-resistant (K1) strains of Plasmodium falciparum and antitrypanosomal activity against Trypanosoma brucei rhodesiense. The dichloromethane extract displayed strong antiplasmodial and antitrypanosomal activities with IC(50) values of 8.10 and 1.10 µg/mL against K1 strain of the malaria parasite and STlB900 strain of T. b. rhodesiense, respectively. Among the compounds evaluated for inhibition of trypomastigotes, both drimane and coloratane sesquiterpenes possessing aldehyde groups at positions 8 and 9 were found to show most antitrypanosomal activity with IC(50) values in the range 0.56-6.4 µM. The antiplasmodial assays also revealed that the six coloratane and six drimane sesquiterpenes isolated from this extract exhibited significant antitrypanosomal activity with IC(50) values ranged from 0.45 to ?114 µM. Among the compounds tested against the malarial parasite P. falciparum 11?-hydroxymuzigadiolide (3) was most active with an IC(50) value of 6.40 µM.

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STRUCTURE OF MUKAADIAL, A MOLLUSCICIDE FROM THE WARBURGIA PLANTS

Abstract: The structure of a new sesquiterpene dialdehyde, mukaadial, isolated from Warburgia stuhlmannii and W. ugandensis and possessing molluscicidal property, has been established by means of spectroscopic and chemical data.

Cited by 37 publications

References 2 publications

From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)

From Bench to Bedside: Natural Products and Analogs for the Treatment of Neglected Tropical Diseases (NTDs)

The genusWarburgia: A review of its traditional uses and pharmacology

Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro

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