Structure of dog and rabbit precursors of atrial natriuretic polypeptides deduced from nucleotide sequence of cloned cDNA

Oikawa, Shinzo; Imai, Mitsuko; Inuzuka, Chikako; Tawaragi, Yasunori; Nakazato, Hiroshi; Matsuo, Hisayuki

doi:10.1016/0006-291x(85)91891-1

Cited by 112 publications

(39 citation statements)

References 20 publications

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“…The cDNA fragment encoding the rabbit atrial natriuretic factor (ANF) was obtained by polymerase chain reaction using primers based on a published sequence. 19) Statistical analysis: Values are expressed as the mean±SE. Comparisons among sham and shunt groups were performed by ANOVA followed by Bonferroni's test.…”

Section: Methodsmentioning

confidence: 99%

Role of Nitric Oxide in the Progression of Cardiovascular Remodeling Induced by Carotid Arterio-Venous Shunt in Rabbits.

et al. 2003

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SUMMARYDespite a variety of biological roles for nitric oxide (NO) in the cardiovascular system, little is known about whether NO is involved in cardiac hypertrophy. We hypothesized that NO production following a sustained increase in shear stress by volumeoverload modifies the level of cardiac hypertrophy independent of hemodynamic changes. Volume-overload was induced by shunt formation between the left common carotid artery and the external jugular vein in 21 rabbits. These shunt rabbits were randomly assigned to 3 groups: shunt with no treatment (n=8), shunt treated with a low dose of N G -nitro-Larginine methyl ester (L-NAME, 0.5 g/L in drinking water, n=8), and shunt with a high dose of L-NAME (1.5 g/L, n=5). Eight sham operated rabbits were used as controls. Treatments were started immediately after operation and were continued for 6 weeks. Chronic volume-overload by shunt formation caused left ventricular dilatation and arterial enlargement proximal to the fistula. The relative wall thickness of the left ventricle was decreased, indicating eccentric cardiac hypertrophy. L-NAME elevated mean arterial blood pressure (P<0.01) and reduced the increment of cardiac output (P<0.05). L-NAME attenuated ventricular weight (P<0.01), ventricular cavity dilatation (P<0.01), and arterial enlargement (P<0.05). The re-capitulation of atrial natriuretic factor mRNA in the hypertrophied left ventricular myocardium by volume-overload was attenuated with L-NAME. In this model with chronic volume-overload, NO plays a pivotal role in the progression of cardiovascular remodeling by regulating the loading conditions of the heart. (Jpn Heart J 2003; 44: 127-137)

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Section: Methodsmentioning

confidence: 99%

Role of Nitric Oxide in the Progression of Cardiovascular Remodeling Induced by Carotid Arterio-Venous Shunt in Rabbits.

et al. 2003

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“…The homology decreases in the introns of the proANP gene (7). The sequences encoding the atrial natriuretic peptide prohormone are more highly conserved between the human and rodent gene than the intervening sequences or the 5 and Figure 1.…”

Section: Proanp Genementioning

confidence: 99%

“…ANPs decrease corticotrophin-releasing factor (CRF) and antiduretic hormone (ADH) from the hypothalamus as well as decrease the circulating concentration of adrenocorticotropin (ACTH) and prolactin from the anterior pituitary. 3 untranslated sequences (7,8). Comparison of human, rat, and mouse genomic sequences and dog and rabbit cDNAs demonstrates maximum homology in the regions encoding proANP (93 of the 126 a.a. residues are identical in all five species), whereas in the hydrophobic leader sequence only 5 of the 25 residues are identical (7,9).…”

Section: Proanp Genementioning

confidence: 99%

Atrial Natriuretic Peptide Prohormone Gene Expression: Hormones and Diseases That Upregulate its Expression

Vesely

2002

IUBMB Life

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“…The moab shows complete crossreactivity with rat ANP I, II, and III, rat ANP (1-28) and human ANP fragment (7-28) while there is no inhibition of 125I-ANP binding by rat ANP fragments (13-28), (18-28) and (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11) (fig. 1).…”

Section: Properties Of the Lla-all Anti-oe-h-anp Moabmentioning

confidence: 99%

“…They have been isolated and sequenced from atria of several mammalian species (e.g. man, rat, bovine) [6]. The predominant lowMr species purified from human atrial is o~-human ANP (ot-h-ANP).…”

Section: Introductionmentioning

confidence: 99%

α‐h‐ANP is the only form of circulating ANP in humans

et al. 1987

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Structure of dog and rabbit precursors of atrial natriuretic polypeptides deduced from nucleotide sequence of cloned cDNA

Cited by 112 publications

References 20 publications

Role of Nitric Oxide in the Progression of Cardiovascular Remodeling Induced by Carotid Arterio-Venous Shunt in Rabbits.

Role of Nitric Oxide in the Progression of Cardiovascular Remodeling Induced by Carotid Arterio-Venous Shunt in Rabbits.

Atrial Natriuretic Peptide Prohormone Gene Expression: Hormones and Diseases That Upregulate its Expression

α‐h‐ANP is the only form of circulating ANP in humans

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