Structure of DNA metal complexes in solution studied by linear and circular dichroism. [Pt(II)(ethylenediamine)(2,2′-dipyridine)]2+ binds strongly to DNA by intercalation. [Cu(II)(2,2′-dipyridine)2]2+ is not intercalated

Nordén, Bengt

doi:10.1016/s0020-1693(00)94983-1

Cited by 15 publications

(1 citation statement)

References 28 publications

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“…4, band at 258 nm). The LD signal of bound metal complexes indicates the orientations they adopt on the DNA [64, 67–69]. In addition, LD is a useful tool for assessing DNA coiling [58, 65, 70, 71].…”

Section: Resultsmentioning

confidence: 99%

Ruthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds?

et al. 2008

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Various interaction modes between a group of six ruthenium polypyridyl complexes and DNA have been studied using a number of spectroscopic techniques. Five mononuclear species were selected with formula [Ru(tpy)L1L2](2−n)+, and one closely related dinuclear cation of formula [{Ru(apy)(tpy)}2{μ-H2N(CH2)6NH2}]4+. The ligand tpy is 2,2′:6′,2″-terpyridine and the ligand L1 is a bidentate ligand, namely, apy (2,2′-azobispyridine), 2-phenylazopyridine, or 2-phenylpyridinylmethylene amine. The ligand L2 is a labile monodentate ligand, being Cl−, H2O, or CH3CN. All six species containing a labile L2 were found to be able to coordinate to the DNA model base 9-ethylguanine by 1H NMR and mass spectrometry. The dinuclear cationic species, which has no positions available for coordination to a DNA base, was studied for comparison purposes. The interactions between a selection of four representative complexes and calf-thymus DNA were studied by circular and linear dichroism. To explore a possible relation between DNA-binding ability and toxicity, all compounds were screened for anticancer activity in a variety of cancer cell lines, showing in some cases an activity which is comparable to that of cisplatin. Comparison of the details of the compound structures, their DNA binding, and their toxicity allows the exploration of structure–activity relationships that might be used to guide optimization of the activity of agents of this class of compounds.Electronic supplementary materialThe online version of this article (doi:10.1007/s00775-008-0460-x) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Ruthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds?

et al. 2008

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Enantioselective interactions of inversion‐labile trigonal iron(II) complexes upon binding to DNA

Härd¹,

Nordén²

1986

Biopolymers

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SynopsisWe studied the interactions of the substitution-inert inversion-labile complexes Fe(bipy):' and Fe(phen):+ [and the inversion-stable complex Ru@ipy):+] with DNA. The association of these complexes to DNA is mainly electrostatic, and Fe(phen);+ shows a more effective binding to DNA than the two bipyridyl complexes, possibly owing to a different binding mode. The interactions are enantioselective, leading to a Pfeiffer shift in the diastereomeric inversion equilibria and an excess of the Aenantiomer of Fe(phen);+ and Fe(bipy):+, which is directly monitorable through CD. The partition constants for the inversion equilibrium range from 1.3 to 2.0 for Fe(bipy):+ and Fe(phen)i+, depending on ionic conditions. From flow LD information about the orientation of the complexes on DNA was obtained it is consistent with a fit of the Aenantiomer in the major groove of the right-handed DNA helix. The mechanisms of interaction are discussed against equilibrium, spectroscopic, and kinetic data.

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ChemInform Abstract: STRUCTURE OF DNA METAL COMPLEXES IN SOLUTION STUDIED BY LINEAR AND CIRCULAR DICHROISM. (PT(II)(ETHYLENEDIAMINE)(2,2′‐DIPYRIDINE))2+ BINDS STRONGLY TO DNA BY INTERCALATION. (CU(II)(2,2′‐DIPYRIDINE)2)2+ IS NOT INTERCALATED

Nordén¹

1979

Chemischer Informationsdienst

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Structure of DNA metal complexes in solution studied by linear and circular dichroism. [Pt(II)(ethylenediamine)(2,2′-dipyridine)]2+ binds strongly to DNA by intercalation. [Cu(II)(2,2′-dipyridine)2]2+ is not intercalated

Cited by 15 publications

References 28 publications

Ruthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds?

Ruthenium polypyridyl complexes and their modes of interaction with DNA: Is there a correlation between these interactions and the antitumor activity of the compounds?

Enantioselective interactions of inversion‐labile trigonal iron(II) complexes upon binding to DNA

ChemInform Abstract: STRUCTURE OF DNA METAL COMPLEXES IN SOLUTION STUDIED BY LINEAR AND CIRCULAR DICHROISM. (PT(II)(ETHYLENEDIAMINE)(2,2′‐DIPYRIDINE))2+ BINDS STRONGLY TO DNA BY INTERCALATION. (CU(II)(2,2′‐DIPYRIDINE)2)2+ IS NOT INTERCALATED

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