“…13,16 By contrast, the bone half-life is very long, from months to years in humans, because of the high affinity of these drugs for solid-phase calcium phosphate, resulting in binding to hydroxyapatite and accumulation in bone. 9,17 Bisphosphonates become trapped in the bone and are only released when the bone is resorbed. Approximately 50% of the absorbed drug is located in the bone.…”