Structure of chitosan thermosensitive gels containing graphene oxide

Tylman, Michał; Pieklarz, Katarzyna; Owczarz, Piotr; Maniukiewicz, Waldemar; Modrzejewska, Zofia

doi:10.1016/j.molstruc.2018.02.065

Cited by 9 publications

(6 citation statements)

References 11 publications

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“…CS is readily available because chitin widely exists in the exoskeleton of crustaceans and cephalopods ( Peers et al., 2020 ; Rinaudo, 2006 ). With excellent physicochemical characteristics and biological properties like stimulus responsiveness, biocompatibility, biodegradability, antibacterial activity, readily film and hydrogel-forming capability, oxygen impermeability ( Ahmed et al., 2020 ), CS has extensive use in drug delivery ( Gooneh-Farahani et al., 2019 ), tissue engineering and regenerative medicine ( Croisier and Jérôme, 2013 ), wound healing ( Tylman et al., 2018 ), food industries ( Paiva et al., 2020 ; Tien et al., 2021 ) and water filtration and purification ( Croitoru et al., 2020 ; Jin et al., 2021 ), etc . Importantly, thanks to abundant amino and hydroxyl active groups on CS main chain, it is easy to modify CS through a variety of interactions such as covalent bonding, hydrogen bonding, and electrostatic interactions, thus conquering its defects of poor mechanical property and solubility ( Croisier and Jérôme, 2013 ).…”

Section: Introductionmentioning

confidence: 99%

Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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Summary Chitosan (CS) and graphene oxide (GO) nanocomposites have received wide attention in biomedical fields due to the synergistic effect between CS which has excellent biological characteristics and GO which owns great physicochemical, mechanical, and optical properties. Nanocomposites based on CS and GO can be fabricated into a variety of forms, such as nanoparticles, hydrogels, scaffolds, films, and nanofibers . Thanks to the ease of functionalization, the performance of these nanocomposites in different forms can be further improved by introducing other functional polymers, nanoparticles, or growth factors. With this background, the current review summarizes the latest developments of CS–GO nanocomposites in different forms and compositions in biomedical applications including drug and biomacromolecules delivery, wound healing, bone tissue engineering, and biosensors. Future improving directions and challenges for clinical practice are proposed as well.

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Section: Introductionmentioning

confidence: 99%

Biomedical applications of chitosan-graphene oxide nanocomposites

Feng¹,

Wang²

2022

iScience

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“…Chitosan (Cs), with low viscosity, was supplied by Sigma– Aldrich (product reference: 50494‐100G‐F) in powder form. The biopolymer has a deacetylation degree of about 79.5%, a molecular weight of approximately 86 kDa, 10 and apparent viscosity <200 mPa s measured at 1% (w/w) in acetic acid at 20°C.…”

Section: Methodsmentioning

confidence: 99%

“…Chitosan (Cs), obtained from the deacetylation of chitin, is one of the most extensively used polysaccharides in various applications because of its interesting material properties. 6,[10][11][12] Chitosan is biodegradable, biocompatible, and non-toxic. The main factors which stimulated the interest in chitosan utilization in various fields are its versatility, its inexpensiveness and its ready availability.…”

Section: Introductionmentioning

confidence: 99%

Bio‐blends of virgin and post‐industrial poly(methyl methacrylate) waste/pristine chitosan: Structure, thermal, and physical properties

Mouffok,

Kaci

2024

Polymer Engineering & Sci

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Polymer blends based on plastic waste and natural biodegradable polymers is an interesting strategy in view of environmental and technical concerns. This article investigates the structure, thermal and physical properties of virgin and post‐industrial polymethyl methacrylate (PMMA) waste/pristine chitosan (Cs) bio‐blends. Waste PMMA was generated by an extrusion process for the manufacturing of sheets. The results of gel permeation chromatography analysis (GPC) show a slight decrease (about 8%) in the average molecular weight of PMMA after extrusion. Fourier transform infrared spectroscopy in attenuated total reflectance mode (FTIR‐ATR) spectra do not reveal changes in the chemical structure of post‐industrial PMMA/Cs blends compared to virgin PMMA/Cs samples, indicating that chain scission reactions are the dominant degradation mechanism of PMMA during processing. Dynamic mechanical analysis (DMA) results reveal a single glass transition temperature () for the blends, implying miscibility of the components. Post‐industrial PMMA/Cs samples exhibit slightly lower values of compared to virgin PMMA/Cs blends. The post‐industrial PMMA waste slightly reduces nano‐mechanical properties and thermal stability of the blends relative to those from virgin PMMA. In contrast, it increases the water uptake of the bio‐blends compared with virgin PMMA.Highlights Chain scission is the dominant degradation mechanism of PMMA during extrusion. Miscibility between the homopolymers within the blends. PMMA waste slightly reduced the nano‐mechanical properties of the bio‐blends. Post‐industrial PMMA waste increased the water uptake of the bio‐blends. Possibility of using post‐industrial PMMA waste by blending with chitosan.

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“…Test hydrogels were weighted the initial mass (W 0 ) and immersed in phosphate-buffered saline (PBS) at 37 °C. At predetermined time intervals (2,4,6,8,12,24,30,54,78,102, and 148 h), test hydrogels were removed from PBS and gently wiped with filter paper, which was then quickly weighed (W t ). The swelling ratio of the hydrogels was determined by the following formula…”

Section: Swelling Ratiomentioning

confidence: 99%

“…In addition, with fine physicochemical characteristics and commendable biological properties, such as biocompatibility, biodegradability, antibacterial activity as well as hydrogel-forming capability, CS has been widely used in tissue engineering, regenerative medicine, and wound healing. [29,30] The thermosensitivity of CS and 𝛽-glycerophosphate (GP) hydrogel has been proved, while the addition of hydroxy propyl cellulose (HPC) shortens the gelation time and enhances the viscosity of the hydrogel. [31] Moreover, graphene oxide (GO), a kind of 2D atomic-thick carbon material, not only displays strong antibacterial activity and outstanding photothermal conversion properties, but also improves the mechanical property of the hydrogel, which makes it a promising candidate in the design of biomedical hydrogels for wound dressings.…”

Section: Introductionmentioning

confidence: 99%

Injectable and Thermosensitive Hydrogel with Platelet‐Rich Plasma for Enhanced Biotherapy of Skin Wound Healing

Liu,

Yang,

Liu

et al. 2024

Adv Healthcare Materials

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The rapid and effective healing of skin wounds resulted from severe injuries and full‐layer skin defects remains a pressing clinical challenge in contemporary medical practice. The reduction of wound infection and rapid healing is helpful to rebuild and repair skin tissue. Here, a thermo‐sensitive chitosan (CS)‐based wound dressing hydrogel incorporating β‐glycerophosphate (GP), hydroxy propyl cellulose (HPC), graphene oxide (GO), and platelet‐rich plasma (PRP) is developed, which exhibits the dual functions of antibacterial properties and repair promotion. GP and HPC enhance the mechanical properties through forming hydrogen bonding connection, while GO produces local heat under near‐infrared light, leading to improved blood circulation and skin recovery. Notably, antibacterial properties against Pseudomonas aeruginosa, and control‐release of growth factors from PRP are also achieved based on the system. In vitro experiments reveal its biocompatibility, and ability to promote cell proliferation and migration. Animal experiments demonstrate that the epithelial repair and collagen deposition can be promoted during skin wound healing in Sprague Dawley rats. Moreover, a reduction in wound inflammation levels and the improvement of wound microenvironment are observed, collectively fostering effective wound healing. Therefore, the composite hydrogel system incorporated with GO and PRP could be a promising dressing for the treatment of skin wounds.This article is protected by copyright. All rights reserved

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Structure of chitosan thermosensitive gels containing graphene oxide

Cited by 9 publications

References 11 publications

Biomedical applications of chitosan-graphene oxide nanocomposites

Biomedical applications of chitosan-graphene oxide nanocomposites

Bio‐blends of virgin and post‐industrial poly(methyl methacrylate) waste/pristine chitosan: Structure, thermal, and physical properties

Injectable and Thermosensitive Hydrogel with Platelet‐Rich Plasma for Enhanced Biotherapy of Skin Wound Healing

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