Structure of bostrycin

Nigrosporins A and B, New Phytotoxic and Antibacterial Metabolites Produced by a FungusNigrospora oryzae

“…The first: column YMC AQ (20 x 250 111m, 5 ~llTI), solvent methanol-H 2 0 (6:4), flow rate 5.0ml/min, tR 24-30 min; the second: column YMC AQ (lOx 300 nm, 5 f.lm), solvent acetonitrile-H,O (3: 7), flow rate 2.0 ml/min, t R 22 min (2). 25 min (3). The final phytotoxic fractions were evaporated to dryness rcsulting in 1.5 mg of 2 and 1.0 mg of 3.…”

“…The EtOAc layer was dried over anhydrous Na 2 S0 4 and concentrated under reduced pressure. The residue was treated by preparative TLC on silica gel using CHCI 3 …”

Auxarthrol A and auxarthrol B: two new tetrahydoanthraquinones from Auxarthron umbrinum

“…The presence of 1,2,3,4-tetrahydroanthraquinones in A. umbrinum extract was unusual, since these octaketide derivatives were identified mainly from the fungal genera Alternaria, Phomopsis, Juniperus, Dactylaria and Bostryconema [3,7,8,9,11,12]. This is the first report of 1,2,3,4-tetrahydroanthraquinones from the fungal genus Auxarthron.…”

Studies on the Synthesis of Derivatives of Marine-Derived Bostrycin and Their Structure-Activity Relationship against Tumor Cells

“…1403 collected from the South China Sea, as well as three bostrycin analogues ( 2 – 4 , Figure 1) [12,13,14]. The originally proposed structure of bostrycin was identified by interpretation of spectral date (IR, UV, MS, 1 H NMR, 13 C NMR) [15,16,17], and then revised by Kelly and his co-workers [18] on the basis of the total synthesis of (+/−)-bostrycin and an X-ray crystal structure of the O -isopropylidene derivative. Subsequently, Larsen’s group [19] revised the absolute configuration of (−)-bostrycin through an elegant asymmetric synthesis of (+)-bostrycin.…”