Structure of a novel highly branched α-glucan enzymatically produced from maltodextrin

Tsusaki, Keiji; Watanabe, Hikaru; Nishimoto, Tetsuya; Yamamoto, Tameyoshi; Kubota, Michio; Chaen, Hiroto; Fukuda, Shigeharu

doi:10.1016/j.carres.2009.08.016

Cited by 38 publications

(28 citation statements)

References 28 publications

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“…IMD is composed solely of glucose, including α-1,6-, α-1,4-, and α-1,3-glucosidic linkages (Tsusaki et al, 2009). IMD contains more than 80% dietary fiber and is watersoluble, thus it functions as a soluble dietary fiber.…”

Section: Introductionmentioning

confidence: 99%

Isomaltodextrin Prevents DSS-induced Colitis by Strengthening Tight Junctions in Mice

Arai

Sakurai

Koya‐Miyata

et al. 2017

FSTR

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Section: Introductionmentioning

confidence: 99%

Isomaltodextrin Prevents DSS-induced Colitis by Strengthening Tight Junctions in Mice

Arai

Sakurai

Koya‐Miyata

et al. 2017

FSTR

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“…IMD is a white powder with no odor, it is freely soluble in water and dissolves into a clear solution, and therefore is unlikely to alter the smell, color or taste of a product in which it is used. The dietary fiber content of IMD is more than 80% (Tsusaki et al, 2009). Therefore, IMD is expected to be applicable for widespread use in foods as a new soluble dietary fiber.…”

Section: Introductionmentioning

confidence: 99%

Safety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch

Sadakiyo

Inoue

Ishida

et al. 2017

Fundam. Toxicol. Sci.

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-A series of safety studies were conducted using isomaltodextrin (IMD), a new dietary fiber that is produced from starch using enzymes. IMD consists of only alpha linkaged glucose molecules, has an average molecular weight of approximately 5,000, is freely soluble in water, and contains greater than 80% fiber (AOAC 2001.03). No genotoxicity was observed when IMD was assayed in standardized bacterial reverse mutation, micronucleus, and chromosome aberration tests. The LD 50 of IMD was found to be more than 2,000 mg/kg in an acute toxicity study in rats, and the no observed adverse effect level (NOAEL) was determined to be 1,000 mg/kg/day in a 90-day subacute gavage toxicity study in rats. No animals died, and no abnormal findings due to consumption of IMD were observed in either of these studies. Both NOAEL values were the highest doses tested. The NOAEL for loose stools was examined in humans in two separate studies. Based on these results, the NOAEL for IMD-related loose stools was considered to be 0.8 g/kg-BW. In a 4-week high-dose ingestion study in humans and a 12-week low-dose ingestion study in humans, laboratory values were found to be within the normal range of variation. The results of the current safety assessment studies suggest that isomaltodextrin is safe for human consumption.

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“…IMD is a white powder with no coloration and odor; it is freely soluble in water and is unlikely to alter the taste or flavor. The dietary fiber content of IMD measured using the enzyme-HPLC method (AOAC 2001.03) is more than 80% as dry solid basis [2]. Resistant maltodextrin (RMD) and polydextrose are also recognized as glucose-based soluble dietary fibers, but IMD is different in that it consists of only α glucosidic linkage and has many α-1,6 glucosidic linkages compared with these materials.…”

Section: Introductionmentioning

confidence: 99%

Attenuation of postprandial blood glucose in humans consuming isomaltodextrin: carbohydrate loading studies

Sadakiyo

Ishida

Inoue

et al. 2017

Food & Nutrition Research

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Background: Isomaltodextrin (IMD) is a novel highly branched α-glucan and its function as a soluble dietary fiber is expected.Objective: The goal of this study was to evaluate the effects of IMD on postprandial glucose excursions in healthy people and to make the mechanism clear.Design: Twenty-nine subjects ingested a solution containing maltodextrin (MD) or sucrose with or without IMD. Fourteen subjects ingested a solution containing glucose with or without IMD. Blood glucose concentrations were then compared between the groups. Furthermore, in vitro digestion, inhibition of digestive enzymes, and glucose absorption tests were conducted.Results: IMD attenuated blood glucose elevation in the subjects with blood glucose excursions at the high end of normal following the ingestion of MD or sucrose or glucose alone. This effect of 5 g IMD was most clear. IMD was digested partially only by small intestinal mucosal enzymes, and maltase and isomaltase activities were weakly inhibited. Furthermore, IMD inhibited the transport of glucose from mucosal side to serosal side.Conclusions: IMD attenuated postprandial blood glucose, after the ingestion of MD or sucrose or glucose. As one of the mechanism, it was suggested that IMD inhibited the absorption of glucose on small intestinal mucosal membrane.

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Structure of a novel highly branched α-glucan enzymatically produced from maltodextrin

Cited by 38 publications

References 28 publications

Isomaltodextrin Prevents DSS-induced Colitis by Strengthening Tight Junctions in Mice

Isomaltodextrin Prevents DSS-induced Colitis by Strengthening Tight Junctions in Mice

Safety assessment of a soluble dietary fiber, isomaltodextrin, enzymatically produced from starch

Attenuation of postprandial blood glucose in humans consuming isomaltodextrin: carbohydrate loading studies

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