Structure−Odor Relationships

Rossiter, K. J.

doi:10.1021/cr950068a

Cited by 267 publications

(193 citation statements)

References 159 publications

Supporting

Mentioning

171

Contrasting

Unclassified

Order By: Relevance

“…First, that molecular shape is an adequate predictor of smell (2,30,32), which currently seems unlikely (33,34). In fact, Drosophila has only 62 olfactory receptors (35), suggesting that a single receptor must generally respond to multiple odorants, but in addition that a single odorant can activate multiple receptors (10,15).…”

Section: Discussionmentioning

confidence: 99%

Molecular vibration-sensing component in Drosophila melanogaster olfaction

Franco

Turin

Mershin

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

176

218

View full text Add to dashboard Cite

A common explanation of molecular recognition by the olfactory system posits that receptors recognize the structure or shape of the odorant molecule. We performed a rigorous test of shape recognition by replacing hydrogen with deuterium in odorants and asking whether Drosophila melanogaster can distinguish these identically shaped isotopes. We report that flies not only differentiate between isotopic odorants, but can be conditioned to selectively avoid the common or the deuterated isotope. Furthermore, flies trained to discriminate against the normal or deuterated isotopes of a compound, selectively avoid the corresponding isotope of a different odorant. Finally, flies trained to avoid a deuterated compound exhibit selective aversion to an unrelated molecule with a vibrational mode in the energy range of the carbon-deuterium stretch. These findings are inconsistent with a shape-only model for smell, and instead support the existence of a molecular vibrationsensing component to olfactory reception.

show abstract

Section: Discussionmentioning

confidence: 99%

Molecular vibration-sensing component in Drosophila melanogaster olfaction

Franco

Turin

Mershin

et al. 2011

Proc. Natl. Acad. Sci. U.S.A.

176

218

View full text Add to dashboard Cite

show abstract

“…Past studies have approached this by varying stimuli along a single and simple physicochemical dimension such as carbon chain length (Laska and Teubner, 1999), or a single and simple perceptual descriptor (Rossiter, 1996) such as "bitter almond-like" (Zakarya et al, 1993). Here, rather than moving from chemistry to perception, we went from perception to chemistry and probed a large set of physicochemical descriptors using an unbiased statistical approach.…”

Section: Discussionmentioning

confidence: 99%

Predicting Odor Pleasantness from Odorant Structure: Pleasantness as a Reflection of the Physical World

Khan

Luk²,

Flinker³

et al. 2007

J. Neurosci.

337

296

View full text Add to dashboard Cite

Although it is agreed that physicochemical features of molecules determine their perceived odor, the rules governing this relationship remain unknown. A significant obstacle to such understanding is the high dimensionality of features describing both percepts and molecules. We applied a statistical method to reduce dimensionality in both odor percepts and physicochemical descriptors for a large set of molecules. We found that the primary axis of perception was odor pleasantness, and critically, that the primary axis of physicochemical properties reflected the primary axis of olfactory perception. This allowed us to predict the pleasantness of novel molecules by their physicochemical properties alone. Olfactory perception is strongly shaped by experience and learning. However, our findings suggest that olfactory pleasantness is also partially innate, corresponding to a natural axis of maximal discriminability among biologically relevant molecules.

show abstract

“…Past studies have approached this by varying stimuli along a single and simple physico-chemical dimension such as carbon chain length (Laska and Teubner, 1999), or a single and simple perceptual descriptor (Rossiter, 1996) such as "bitter almond like" (Zakarya et al, 1993). Here, rather than moving from chemistry to perception, we went from perception to chemistry, and probed a large set of physicochemical descriptors using an unbiased statistical approach.…”

Section: Discussionmentioning

confidence: 99%

Predicting Odor Pleasantness from Odorant Structure: Pleasantness as a Reflection of the Physical World

Khan¹,

Luk²,

Flinker³

et al. 2009

View full text Add to dashboard Cite

The public reporting burden for this collection of information is estimated to average 1 hour per response, including the time for reviewing instructions, searching existing data sources, gathering and maintaining the data needed, and completing and reviewing the collection of information.Send comments regarding this burden estimate or any other aspect of this collection of information, including suggesstions for reducing this burden, to Washington

show abstract

Structure−Odor Relationships

Cited by 267 publications

References 159 publications

Molecular vibration-sensing component in Drosophila melanogaster olfaction

Molecular vibration-sensing component in Drosophila melanogaster olfaction

Predicting Odor Pleasantness from Odorant Structure: Pleasantness as a Reflection of the Physical World

Predicting Odor Pleasantness from Odorant Structure: Pleasantness as a Reflection of the Physical World

Contact Info

Product

Resources

About