Structure, mechanism and application of vinyl alcohol oligomers grafted onto poly(3-hydroxybutyrate): a proposal

Abstract

Oligomers of poly(vinyl alcohol) were grafted onto poly(3-hydroxybutyrate) (PHB) by radiation-induced polymerization. The aim of this study was to elucidate the structure of these copolymers using nuclear magnetic resonance (heteronuclear multiple quantum coherence) spectroscopy supported by dynamic light scattering (DLS) and atomic force microscopy (AFM). It was concluded that vinyl alcohol (VA) was grafted onto PHB for the methylenic and methynic sites. A mechanism for the grafting reaction was proposed based on the experimental evidence. AFM and DLS allowed the characterization of the particles obtained from P(HB-g-VA). The prepared materials showed suitable properties for use in drug delivery systems.

Novel Poly(3-hydroxybutyrate-g-vinyl alcohol) Polyurethane Scaffold for Tissue Engineering

“…The structure of P(3HB) molecules is very inactive, with lack of functional groups, bringing a hydrophobic nature. The introduction of polyvinyl alcohol groups to the polyester structure provides a greater hydrophilicity, biodegradability, and also functionality, as demonstrated in our previous works 39 40 41 . This strategy promotes a new alternative for application.…”

“…Surprisingly, this copolymer showed the ability to produce electricity by reorientation of the molecules with gradual stress compression 40 . It is known that this grafted P(3HB) is also biodegradable and biocompatible, which could be used to prepare nanoparticles with potential application as drug delivery systems 41 . Therefore, we proposed the use of P(3HB-g-VA) for the synthesis of a polyurethane foam scaffold.…”

Improve the Native Characteristics of Polysaccharides by Grafting Through the Gamma Radiation: A Review

“…Hypothetically, radicals produced both in natural polymer and in monomer might initiate covalent bonds between the reagents. However, the contribution of reactive sites situated in polymeric matrices in grafting procedures has not been determined yet and made an effort to determine the role of radicals produced in selected polymers on radiation-induced grafting [34].…”