Structure, mechanical characteristics and in vitro degradation, cytotoxicity, genotoxicity and mutagenicity of novel biodegradable Zn–Mg alloys

Kubásek, Jiří; Vojtěch, Dalibor; Jablonská, Eva; Pospíšilová, Iva; Lipov, Jan; Ruml, Tomáš

doi:10.1016/j.msec.2015.08.015

Cited by 277 publications

(177 citation statements)

References 48 publications

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“…Alloying elements of Zn have the role of strengthening the matrix since Zn-based alloys suffer from low mechanical properties. To improve the mechanical properties of pure Zn, some elements such as Mg, Ca, Sr, Sn and Fe were added into Zn-based alloys [56,70,117,149]. Vojtech et al [70] developed as cast Zn-Mg alloys and studied their mechanical properties and corrosion behavior.…”

Section: Zincmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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Abstract:Owing to significant advantages of bioactivity and biodegradability, biodegradable metallic materials such as magnesium, iron, and zinc and their alloys have been widely studied over recent years. Metallic wires with superior tensile strength and proper ductility can be fabricated by a traditional metalworking process (drawing). Drawn biodegradable metallic wires are popular biodegradable materials, which are promising in different clinical applications such as orthopedic fixation, surgical staples, cardiovascular stents, and aneurysm occlusion. This paper presents recent advances associated with the application of biodegradable metallic wires used in dental and orthopedic fields. Furthermore, the effects of some parameters such as the surface modification, alloying elements, and fabrication process affecting the degradation rate as well as biocompatibility, bioactivity, and mechanical stability are reviewed in the most recent works pertaining to these materials. Finally, possible pathways for future studies regarding the production of more efficient biodegradable metallic wires in the regeneration of bone defects are also proposed.

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Section: Zincmentioning

confidence: 99%

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Asgari

Hang

Chang

et al. 2018

Metals

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“…Alloys with 0·5 wt% of magnesium have been shown to possess a suitable combination of strength and elasticity, and 3 wt% is a eutectic point of the zinc-magnesium system. 11,19,20 For the silver alloys, Liu et al…”

Section: Materials Fabrication and Characterizationmentioning

confidence: 99%

“…18 More recently, a number of studies were published suggesting zinc-magnesium, zinc-aluminum (Al), zinc-lithium (Li) and zinc-silver (Ag) as potential biodegradable alloys. [19][20][21][22] The zinc-silver alloy was shown to possess high mechanical strength as well as superplasticity. 22 Current knowledge suggests zinc alloys to be a promising new class of biodegradable metals.…”

Section: Introductionmentioning

confidence: 99%

Zn-Mg and Zn-Ag Degradation Mechanism Under Biologically Relevant Conditions

Törne

Khan

Örnberg

et al. 2017

Surface Innovations

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Zinc (Zn) alloys form a promising new class of biodegradable metals that combine suitable mechanical properties with the favorable degradation properties of pure zinc. However, the current understanding of the influence of alloying elements on the corrosion of zinc alloys, in biologically relevant media, is limited. The authors studied the degradation of three alloys, zinc-4 wt% silver (Ag), zinc-0·5 wt% magnesium (Mg) and zinc-3 wt% magnesium by in situ electrochemical impedance spectroscopy (EIS). After exposure for 1 h or 30 d, the samples were characterized by infrared spectroscopy and scanning electron microscopy. The presence of secondary phases in the alloy microstructure induced selective corrosion and increased the degradation rate. EIS analysis revealed an increase in surface inhomogeneity already at short (hours) immersion times. The microgalvanic corrosion of the zinc-silver alloy resulted in enrichment of the AgZn 3 phase at the sample surface. The enrichment of silver and potential release of AgZn 3 particles may result in complications during the tissue regeneration. The zinc-magnesium alloy surface was depleted of the magnesium-rich phase after 8-12 d. The selective dissolution caused local precipitation of corrosion products and a thicker corrosion layer with larger pore size consistent with increased corrosion rate.

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“…Hot extruded alloy with 0.8 wt % of magnesium reaches the ultimate tensile strength of approximately 300 MPa and a Vickers hardness of approximately 80 HV5. With the content of 1.6 wt % of magnesium, hot extruded materials reach the ultimate tensile strength of approximately 360 MPa and a Vickers hardness of approximately 97 HV5 [27].…”

Section: Introductionmentioning

confidence: 99%

“…The influence of the preparation method and its parameters on mechanical properties is studied only marginally [17,[27][28][29][30].…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Zinc Materials Prepared by Powder Metallurgy

Zapletal

Krystýnová

Březina

et al. 2017

Metals

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Abstract:The use of zinc-based materials as biodegradable materials for medical purposes is offered as a possible alternative to corrosion-less resistant magnesium-based materials. Zinc powders with two different particle sizes (7.5 µm and 150 µm) were processed by the methods of powder metallurgy: cold pressing, cold pressing followed by sintering and hot pressing. The microstructure of prepared materials was evaluated in terms of light optical microscopy, and the mechanical properties were analyzed with Vickers microhardness testing and three-point bend testing. Fractographic analysis of broken samples was performed with scanning electron microscopy. Particle size was shown to have a significant effect on compacts mechanical properties. The deformability of 7.5 µm particle size powder was improved by increased temperature during the processing, while in the case of larger powder, no significant influence of temperature was observed. Bending properties of prepared materials were positively influenced by elevated temperature during processing and correspond to the increasing compacting pressures. Better properties were achieved for pure zinc prepared from 150 µm particle size powder compared to materials prepared from 7.5 µm particle size powder.

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Structure, mechanical characteristics and in vitro degradation, cytotoxicity, genotoxicity and mutagenicity of novel biodegradable Zn–Mg alloys

Cited by 277 publications

References 48 publications

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Biodegradable Metallic Wires in Dental and Orthopedic Applications: A Review

Zn-Mg and Zn-Ag Degradation Mechanism Under Biologically Relevant Conditions

Preparation and Characterization of Zinc Materials Prepared by Powder Metallurgy

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