Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

Ryseck, Rolf-Peter; Macdonald-Bravo, H; Mattei, Marie-Genevı̀eve; Ruppert, Siegfried; Bravo, Rodrigo

doi:10.1002/j.1460-2075.1989.tb08494.x

Cited by 184 publications

(116 citation statements)

References 49 publications

Supporting

Mentioning

109

Contrasting

Order By: Relevance

“…Nr4a1 (also known as nur77 and NGFI-B) belongs to a subfamily of orphan nuclear receptors, whose other members are Nr4a2 [also known as Rnr-1 (ribonucleotide reductase-1), Not, and Nurr1] and Nr4a3 [also known as Nor-1 (neuron-derived orphan receptor-1) and Tec], all of which function as transcription factors (Ryseck et al, 1989;Steinmetz et al, 2001). Several studies have implicated Nr4a1 and Nr4a2 as CREB target genes (Fass et al, 2003;Darragh et al, 2005;von Hertzen and Giese, 2005ab).…”

Section: Discussionmentioning

confidence: 99%

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Vecsey¹,

Hawk²,

Lattal³

et al. 2007

Journal of Neuroscience

757

761

View full text Add to dashboard Cite

Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance both memory and synaptic plasticity. The current model for the action of HDAC inhibitors assumes that they alter gene expression globally and thus affect memory processes in a nonspecific manner. Here, we show that the enhancement of hippocampus-dependent memory and hippocampal synaptic plasticity by HDAC inhibitors is mediated by the transcription factor cAMP response element-binding protein (CREB) and the recruitment of the transcriptional coactivator and histone acetyltransferase CREB-binding protein (CBP) via the CREB-binding domain of CBP. Furthermore, we show that the HDAC inhibitor trichostatin A does not globally alter gene expression but instead increases the expression of specific genes during memory consolidation. Our results suggest that HDAC inhibitors enhance memory processes by the activation of key genes regulated by the CREB:CBP transcriptional complex.

show abstract

Section: Discussionmentioning

confidence: 99%

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Vecsey¹,

Hawk²,

Lattal³

et al. 2007

Journal of Neuroscience

757

761

View full text Add to dashboard Cite

show abstract

“…The apoptotic process is activated by the expression of Nur77, an orphan steroid receptor [67][68][69]. Constitutive expression of Nur77 in thymocytes results in a dramatic involution of the thymus, whereas expression of a dominant-negative Nur77 interferes with negative selection [70,71].…”

Section: Biological Roles Of Class Iia Hdacsmentioning

confidence: 99%

Class II histone deacetylases: versatile regulators

2003

View full text Add to dashboard Cite

Histone acetylation and deacetylation play essential roles in modifying chromatin structure and regulating gene expression in eukaryotes. Histone deacetylases (HDACs) catalyze the deacetylation of lysine residues in the histone N-terminal tails and are found in large multiprotein complexes with transcriptional co-repressors. Human HDACs are grouped into three classes based on their similarity to known yeast factors: class I HDACs are similar to the yeast transcriptional repressor yRPD3, class II HDACs to yHDA1 and class III HDACs to ySIR2. In this review, we focus on the biology of class II HDACs. These newly discovered enzymes have been implicated as global regulators of gene expression during cell differentiation and development. We discuss their emerging biological functions and the molecular mechanisms by which they are regulated.

show abstract

“…Amplified products were separated in 6% polyacrylamide gels. Northern analysis using 15 g total spleen RNA was performed as described previously (18). Equal loading was controlled by methylene blue staining of the membrane.…”

Section: Rna Analysesmentioning

confidence: 99%

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

Weih

Yilmaz

Weih

2001

The Journal of Immunology

205

194

View full text Add to dashboard Cite

High levels of the Rel/NF-κB family member RelB are restricted to specific regions of thymus, lymph nodes, and Peyer’s patches. In spleen, RelB is expressed in periarteriolar lymphatic sheaths, germinal centers (GCs), and the marginal zone (MZ). In this study, we report that RelB-deficient (relB−/−) mice, in contrast to nfkb1−/−, but similar to nfkb2−/− mice, are unable to form GCs and follicular dendritic cell networks upon Ag challenge in the spleen. RelB is also required for normal organization of the MZ and its population by macrophages and B cells. Reciprocal bone marrow transfers demonstrate that RelB expression in radiation-resistant stromal cells, but not in bone marrow-derived hemopoietic cells, is required for proper formation of GCs, follicular dendritic cell networks, and MZ structures. However, the generation of MZ B cells requires RelB in hemopoietic cells. Expression of TNF ligand/receptor family members is only moderately altered in relB−/− splenocytes. In contrast, expression of homing chemokines is strongly reduced in relB−/− spleen with particularly low mRNA levels of the chemokine B lymphocyte chemoattractant. Our data indicate that activation of p52-RelB heterodimers in stromal cells downstream of TNF/lymphotoxin is required for normal expression of homing chemokines and proper development of spleen microarchitecture.

show abstract

Structure, mapping and expression of a growth factor inducible gene encoding a putative nuclear hormonal binding receptor.

Cited by 184 publications

References 49 publications

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Histone Deacetylase Inhibitors Enhance Memory and Synaptic Plasticity via CREB: CBP-Dependent Transcriptional Activation

Class II histone deacetylases: versatile regulators

Essential Role of RelB in Germinal Center and Marginal Zone Formation and Proper Expression of Homing Chemokines

Contact Info

Product

Resources

About