Structure, Localization of Tumor and Tumorlike Diseases of the Oral Cavity

Костина, И Н

doi:10.18481/2077-7566-2014-0-4-33-39

Cited by 2 publications

(2 citation statements)

References 9 publications

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“…В наших наблюдениях поражение языка в контрольной группе составило 29 (63%) случаев, в основной 27 (62%) (p=0,981), запущенных стадий -29 (63%) и 24 (56%) (p=0,488) соответственно [5]. Высокий процент злокачественных новообразований СОПР был представлен эпителиальным плоскоклеточным ороговевающим раком -36 (78%) в контрольной группе и 33 (77%) (p=0,864) в основной группе, что также не противоречит данным научных публикаций [2,4,10].…”

Section: Discussionunclassified

“…Биопсия образований СОПР является инвазивным методом взятия ткани для гистологического исследования с целью дифференциальной диагностики и установления диагноза [4]. Данная процедура проводится в основном в специализированных учреждениях здравоохранения и входит в стандарт и алгоритм обследования пациентов при подозрении на онкопатологию.…”

Section: Identification Of the Site For Biopsy In Oral Mucosa Cancer unclassified

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Identification of the site for biopsy in oral mucosa cancer diagnostics

Orlov

Gabrielyan

Григорьевич³

et al. 2020

Science and Innovations in Medicine

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Objective to refine the method of incisional biopsy in the diagnosis of oral mucosa cancer using the auto-fluorescent stomatoscopy. Materials and method.The study was conducted on the base of the Samara Regional Clinical Oncology Center. The inclusion criterion for patients was the diagnose of the oral mucosa cancer of various localization. Patients were divided into 2 groups. The main group included patients (n=43), who were being diagnosed for cancer with the help of optimized incisional biopsy of the oral mucosa formations, using the "AFS-400" autofluorescence complex and glasses with a green light filter for identification. The patients of the control group (n=46) received the standard biopsy procedure under direct vision. Results.The first incisional biopsies revealed cancer in 25 (54%) patients of the control group and in 36 (84%) patients of the main group. A histological verification of the diagnosis was necessary in 7 (16%) patients of the main group and required the second biopsy. In the control group, for the same purpose, 17 (37%) patients underwent the second biopsy and 4 (9%) patients required the third biopsy procedure. Exophytic-papillary forms of cancer were the most complex for histological verification. The primary biopsy of these cases was effective in 16 (37%) patients in the main group and in 8 (17%) patients in the control group (p = 0.036). In patients with initial stages of cancer (I-II), with the first incision biopsy, the histological verification of cancer was achieved in 16 (37%) cases in the main group and in 8 (17%) cases in the control group (p = 0.036). Conclusion.The use of the "AFS-400" autofluorescent complex and glasses with a green light filter for incisional biopsy of oral mucosal formations allows histological verification of cancer with the first biopsy in 84% of cases, including in stages I - II in 16 (37%) cases and in exophytic papillary forms in 16 (37%) cases. The significant difference was registered for the similar indicators of the control group (p = 0.036).

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Section: Identification Of the Site For Biopsy In Oral Mucosa Cancer unclassified

Identification of the site for biopsy in oral mucosa cancer diagnostics

Orlov

Gabrielyan

Григорьевич³

et al. 2020

Science and Innovations in Medicine

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Optimization of examination methods in the diagnosis of precancerous and malignant oral mucosal lesions

et al. 2022

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Relevance. The prevalence of oral mucosal diseases among the Russian population varies from 3% to 20% [7]. Precancerous and malignant diseases are a particular problem. More than nine thousand new cases of malignant oral mucosal lesions are registered annually in the Russian Federation, and yearly mortality rates reach 34%. Unfortunately, despite being externally located, the rate of late-diagnosed malignant oral mucosal neoplasms reaches 60%-70% in various regions of the Russian Federation [2]. Thus, one of the most urgent problems in dentistry and oncology is the early diagnosis of precancerous and malignant oral mucosal lesions. As a rule, precancerous lesions are not diagnosed at an early stage since there are no visible clinical signs, and therefore patients do not seek medical attention [8]. An accurate diagnosis requires both basic and additional examination methods. In turn, the conventional methods include traditional inspection, which largely depends on the clinician's experience. Besides the clinical examination, additional techniques are used, namely, fluorescence examination and biopsy [9-11]. Subsequently, optimizing the diagnosis of oral mucosal lesions is the most promising direction in practical healthcare, both in the dental and oncology practice, for early detection and reduction of advanced stages of malignant oral mucosal lesions. Thus, the study confirmed that the development and application of modern approaches are necessary for the early diagnosis of oral mucosal lesions. Purpose. The study aimed to improve the outcome of oral mucosal precancerous and malignant lesion diagnosis by upgrading examination methods. Material and methods. The study included 147 patients with oral mucosal lesions, referred to the oncologists of Samara regional clinical oncology centre by the city polyclinics. The patients were divided into two groups according to the examination methods. The control group patients, 63 people, had a conventional examination by a dentist (patient interview, inspection, palpation) and an incisional biopsy by an oncologist. The main group consisted of 84 patients, who, besides conventional dental examination, were evaluated by a new – developed and put into practice – technique with point and index score and subsequent incisional biopsy performed by an oncologist. The studied patients were comparable by gender, age and localization. The study assessed the effectiveness of the new method for the diagnosis of precancerous lesions (PL) and malignant lesions (ML) by matching the Need for Histology Verification Index (NHVI) value equal to 5 points or more and histopathology results.Results. In the main group, 71 out of 84 patients scored 5 or more according to the new method, and 13 patients scored less than 5. Patients with a low score had a non-surgical treatment, 11 patients reached remission, and two patients were referred to an oncologist for a biopsy, which confirmed oral mucosa PL and ML. The patient complaints in both groups demonstrated that pain and bleeding were more frequent in the control group compared to the main one. The evaluation of clinical examination data revealed more erosions in the control group and nonremovable plaque and hyperplasia in the main group. The incisional biopsy detected more PL and ML in the main group (p = 0.001), and early malignant lesions were in 23% versus 5% in the control group. The new method specificity in oral mucosal PL and ML diagnosis was 55%, sensitivity – 97%, accuracy – 87%, whereas the conventional examination specificity was 28%, sensitivity – 84%, and accuracy – 60%.Conclusion. The administered improved method for examination of patients with oral mucosal lesions and the compulsory use of autofluorescence examination and risk factor score assessment allowed us to identify PL and ML in 88% and to diagnose more PL and ML at early stages, which explains the need to use this method in the clinical practice for the early diagnosis of lesions.

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Structure, Localization of Tumor and Tumorlike Diseases of the Oral Cavity

Abstract: <p>Tumor, tumor-like diseases of the oral cavity diverse. In the literature cases of these diseases, however, there are contradictions in the notes on the frequency of occurrence, gender differences, the structure of injury, and a description of such diseases in one study missing. </p>

Cited by 2 publications

References 9 publications

Identification of the site for biopsy in oral mucosa cancer diagnostics

Identification of the site for biopsy in oral mucosa cancer diagnostics

Optimization of examination methods in the diagnosis of precancerous and malignant oral mucosal lesions

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