Structure, histochemistry, and ultrastructure of the epithelium and stroma in the gerbil (Meriones unguiculatus) female prostate

Santos, Fernanda C. A.; Carvalho, Hernandes F.; Góes, Rejane Maira; Taboga, Sebastião Roberto

doi:10.1016/s0040-8166(03)00071-5

Cited by 51 publications

(56 citation statements)

References 23 publications

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“…Fibroblasts and smooth muscle cells (thick arrows); epithelial cell nuclei (arrows). (Brambell and Davis, 1940;Mahoney and Witschi, 1947;Shehata, 1972Shehata, , 1975Shehata, , 1980Gross and Didio, 1987;Satoh et al, 2001;Flamini et al, 2002;Santos et al, 2003Santos et al, , 2007. In the gerbil Meriones unguiculatus, the prostate is found in $ 80% of the animals , a proportion very similar to that in human females (Zaviacic, 1999).…”

Section: Discussionmentioning

confidence: 99%

Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Biancardi

Santos

Madi-Ravazzi

et al. 2010

The Anatomical Record

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The female prostate (Skene's paraurethral gland) in the rat is morphologically similar to the ventral lobe of male adults and has been described in other rodent species and humans. Previous studies on prostate morphogenesis suggest that female Wistar rats (Rattus norvegicus) do not develop this gland due to the absence of testosterone during the embryonic and neonatal periods. On the other hand, studies conducted in our laboratory have shown that some females of this species can present an undeveloped but functional prostate. Recent studies on this gland have caused scientific interest because, besides being active in the processes of synthesis and secretion of prostatic material, it is also targeted by both malignant and benign lesions, mainly during senescence. Thus, this work aims to evaluate the structure of female prostate of adult rats (Rattus norvegicus) under normal conditions and under the effect of testosterone treatment and carry out comparative studies on the ventral prostate of young and adult male rats. Morphological and morphometric stereological analyses and immunocytochemical and ultrastructural studies were conducted. The results have shown that the prostate gland of rats exposed to androgen therapy have experienced intense growth, becoming more active in relation to synthesis and secretion. It may be concluded that the prostate in control adult female rats is morphologically very similar to the prostatic ventral lobe of young male rats. Besides, under androgenic action, the female prostate grows considerably and becomes similar to the prostatic ventral lobe in male adults.

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Section: Discussionmentioning

confidence: 99%

Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Biancardi

Santos

Madi-Ravazzi

et al. 2010

The Anatomical Record

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“…This species of rodent is a promising model for studies involving the prostate, as unlike other laboratory rodents, a functional prostate is present in females. Furthermore, this species has greater sensitivity to hormone treatments 4, 26, 27, 28, 29. For this purpose, immunofluorescence assays were performed on prostatic tissue, in addition to cultured prostatic cells.…”

Section: Introductionmentioning

confidence: 99%

Telocytes play a key role in prostate tissue organisation during the gland morphogenesis

Sanches

Maldarine

Zani

et al. 2017

J Cellular Molecular Medi

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Telocytes are CD34‐positive interstitial cells, known to exert several functions, one of which is a role in tissue organisation, previously demonstrated by telocytes in the myocardium. The existence of telocytes in the prostate has recently been reported, however, there is a lack of information regarding the function of these cells in prostate tissue, and information regarding the possible role of these cells in prostatic development. This study used immunofluorescence techniques in prostate tissue and prostatic telocytes in culture to determine the relationship between telocytes and prostate morphogenesis. Furthermore, immunofluorescent labelling of telocytes was performed on prostate tissue at different stages of early postnatal development. Initially, CD34‐positive cells are found at the periphery of the developing alveoli, later in the same region, c‐kit‐positive cells and cells positive for both factors are verified and CD34‐positive cells were predominantly observed in the interalveolar stroma and the region surrounding the periductal smooth muscle. Fluorescence assays also demonstrated that telocytes secrete TGF‐β1 and are ER‐Beta (ERβ) positive. The results suggest that telocytes play a changing role during development, initially supporting the differentiation of periductal and perialveolar smooth muscle, and later, producing dense networks that separate alveoli groups and form a barrier between the interalveolar region and periurethral smooth muscle. We conclude that telocytes play a relevant role in prostate tissue organisation during postnatal development.

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“…In addition, the Mongolian gerbil (Meriones unguiculatus) has been recognized in some biomedical sciences, such as immunology (Nawa et al, 1994), physiology (Nolan et al, 1990), and morphology (Custódio et al, 2004;Pinheiro et al, 2003;Santos et al, 2003Santos et al, , 2006Corradi et al, 2004). More recently, gerbil has also been suggested as a suitable model for studies on mammalian aging (Pegorin de Campos et al, 2006).…”

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confidence: 99%

Tissue evidence of the testosterone role on the abnormal growth and aging effects reversion in the gerbil (Meriones unguiculatus) prostate

2006

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Prostate differentiation during embryogenesis and its further homeostatic state maintenance during adult life depend on androgens. Abundant biological data suggest that androgens play an important role in the development of the prostate cancer and other prostatic diseases. The objective of this work was to evaluate the effects of the testosterone supplementation in gerbil (a new experimental model) at different ages. Tissues from experimental animals were studied by histological and histochemistry procedures, androgen receptor immunohistochemistry assay, morphometricstereological analysis, and transmission electron microscopy (TEM). After the treatment were observed increase of prostate weight and epithelium height in all ages studied. In some adult and aged treated animals, hyperplasic and displasic process were observed, including prostatic intraepithelial neoplasias and adenocarcinomas. Increase of the thickness of the smooth muscle cell (SMC) layer was observed in pubescent and adult animals and TEM revealed apparent SMC hypertrophy. An apparent increase in the frequency of blood vessels distributed by the subepithelial stroma in the treated animals was noticed. Reversion of the natural effects of aging on the prostate was observed in the aged treated animals in some acini of the gland. These data demonstrate that the gerbil prostate is susceptible to androgenic action at the studied ages and it can serve, for example, as experimental model to studies of prostate neoplasic process induction and hormonal therapy in aged animals. Anat Rec Part A, 288A:1190-1200, 2006.2006 Wiley-Liss, Inc.Key words: testosterone; prostate; stroma; epithelium; gerbil Androgens are steroid hormones that induce the differentiation and maturation of the male reproductive organs and the development of the male secondary sex characteristics. Prostate differentiation during embryogenesis and its further homeostatic state maintenance during adult life depend on androgens. The normal prostatic epithelium is composed of different cells types that have varying androgen sensitivities, including androgen-independent basal stem cells, androgen-dependent luminal secretory cells, and androgen-independent but androgen-sensitive

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Structure, histochemistry, and ultrastructure of the epithelium and stroma in the gerbil (Meriones unguiculatus) female prostate

Cited by 51 publications

References 23 publications

Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Testosterone Promotes an Anabolic Increase in the Rat Female Prostate (Skene's Paraurethral Gland) Which Acquires a Male Ventral Prostate Phenotype

Telocytes play a key role in prostate tissue organisation during the gland morphogenesis

Tissue evidence of the testosterone role on the abnormal growth and aging effects reversion in the gerbil (Meriones unguiculatus) prostate

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