Structure—Function Studies of Human Monoclonal Antibodies to Pneumococcus Type 3 Polysaccharide

Shaw, Denise R.; Kirkham, Perry M.; Schroeder, Harry W.; Roben, Paul; Silverman, Gregg J.

doi:10.1111/j.1749-6632.1995.tb55849.x

Cited by 18 publications

(2 citation statements)

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“…Such observed germline gene restriction is not unique to chlamydial carbohydrate antigens and has been observed in the antibody response to several other T-cell independent antigens, including the capsular polysaccharides from Haemophilus influenzae in both mice and humans , , Streptococcus pneumoniae , Cryptococcus neoformans , , and Neisseria meningitidis . This evidence of an inherited immune response is of particular importance for T-cell independent antigens, which have an increased dependency on the primary germline gene response.…”

Section: Discussionmentioning

confidence: 81%

Antibodies Raised Against Chlamydial Lipopolysaccharide Antigens Reveal Convergence in Germline Gene Usage and Differential Epitope Recognition

et al. 2009

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Section: Discussionmentioning

confidence: 81%

Antibodies Raised Against Chlamydial Lipopolysaccharide Antigens Reveal Convergence in Germline Gene Usage and Differential Epitope Recognition

et al. 2009

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“…This PDF file includes: Materials and Methods Figs. S1 and S7 References (76)(77)(78)(79)(80)(81)(82)(83) Other Supplementary Material for this manuscript includes the following: Data files S1 and S4 MDAR Reproducibility Checklist View/request a protocol for this paper from Bio-protocol.…”

Section: Supplementary Materialsmentioning

confidence: 99%

T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens

et al. 2023

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Marginal zone (MZ) B cells are one of the main actors of T-independent (TI) responses in mice. To identify the B cell subset(s) involved in such responses in humans, we vaccinated healthy individuals with Pneumovax, a model TI vaccine. By high-throughput repertoire sequencing of plasma cells (PCs) isolated 7 days after vaccination and of different B cell subpopulations before and after vaccination, we show that the PC response mobilizes large clones systematically, including an immunoglobulin M component, whose diversification and amplification predated the pneumococcal vaccination. These clones could be mainly traced back to MZ B cells, together with clonally related IgA + and, to a lesser extent, IgG + CD27 + B cells. Recombinant monoclonal antibodies isolated from large PC clones recognized a wide array of bacterial species from the gut flora, indicating that TI responses in humans largely mobilize MZ and switched B cells that most likely prediversified during mucosal immune responses against bacterial antigens and acquired pneumococcal cross-reactivity through somatic hypermutation.

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Antibody Recognition of Chlamydia LPS: Structural Insights of Inherited Immune Responses

Blackler

Müller‐Loennies

Brade

et al. 2011

Anticarbohydrate Antibodies

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Structure—Function Studies of Human Monoclonal Antibodies to Pneumococcus Type 3 Polysaccharide

Cited by 18 publications

References 10 publications

Antibodies Raised Against Chlamydial Lipopolysaccharide Antigens Reveal Convergence in Germline Gene Usage and Differential Epitope Recognition

Antibodies Raised Against Chlamydial Lipopolysaccharide Antigens Reveal Convergence in Germline Gene Usage and Differential Epitope Recognition

T-independent responses to polysaccharides in humans mobilize marginal zone B cells prediversified against gut bacterial antigens

Antibody Recognition of Chlamydia LPS: Structural Insights of Inherited Immune Responses

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