Structure– Function Relationships of Hydrophobic Proteins SP-B and SP-C in Pulmonary Surfactant

́rez-Gil, Jesu ́s Pe; Cruz, Antonio; Plasencia, Ine ́s

doi:10.1201/b14169-10

Cited by 1 publication

(2 citation statements)

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“…Finding factors that affect the nonequilibrium state and metastability of lung surfactant is an important issue in understanding lung surfactant function. Recently captive bubble studies showed that fast compression can be a way to improve the film metastability of lung surfactant (18,19,59). In this section, we reveal that film metastability can be enhanced through the intermolecular interaction using tripalmitin in the mixed monolayer with DPPC.…”

Section: Dppcd62-tripalmitin Mixed Monolayermentioning

confidence: 76%

“…Using these physiochemical approaches, scientists have investigated the molecular-level mechanisms, models and concepts to explain the unique lung surfactant properties. For example, three different models, a "selective adsorption" model, a "selective squeeze-out'' model and a "supercompressed fluid" model have been proposed to explain how the near-zero surface tension at the end of exhalation is attained (1,2,58,59). A surfaceassociated reservoir concept has been proposed to explain how surfactant proteins SP-B and SP-C enhance adsorption and respreading of lung surfactant during the breathing cycle (1 6,26,28,29,32,36,38,49).…”

Section: Introductionmentioning

confidence: 99%

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New Insights into Lung Surfactant Monolayers Using Vibrational Sum Frequency Generation Spectroscopy

Allen

2006

Photochem Photobiol

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At the air-water interface, interfacial molecular structure, intermolecular interactions, film relaxation and film respreading of model lung surfactant monolayers were studied using vibrational sum frequency generation (VSFG) spectroscopy combined with a Langmuir film balance. Chain-perdeuterated dipalmitoylphosphatidylcholine (DPPC-d62), palmitoyloleoyl-phosphatidylglycerol (POPG), palmitic acid (PA) and tripalmitin were investigated. In the DPPC-d62-PA binary monolayer, PA showed a condensing effect on the DPPC chains. On the contrary, in the DPPC-d62-POPG binary monolayer, POPG showed a fluidizing effect on the DPPC chains. In the ternary monolayer system of DPPC-d62-POPG-PA, the balance between the fluidizing and the condensing effect was also observed. In addition, the film relaxation behavior of DPPC-d62 and the enhanced film stability of DPPC-d62 caused by the addition of tripalmitin were observed. Real-time VSFG was also employed to study the respreading properties of a complex lung surfactant mixture containing DPPC-d62, POPG, PA and KL4 (a mimic of SP-B) peptide, which revealed DPPC enrichment after film compression.

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Section: Dppcd62-tripalmitin Mixed Monolayermentioning

confidence: 76%

Section: Introductionmentioning

confidence: 99%