Structure–Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time-Domain and Spectral-Domain OCT Devices

Pinto, Luciano Ribeiro; Costa, Elaine Fiod; Melo, Luiz Alberto S.; Gross, Paula Blasco; Sato, Eduardo Toshio; Almeida, Andrea Pereira; Maia, André; Paranhos, Augusto

doi:10.1167/iovs.13-13664

Cited by 26 publications

(22 citation statements)

References 29 publications

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“…These findings corresponded to those of Pinto et al, 39 who reported that temporal RNFL thickness was significantly related to the corresponding VF sensitivity measured using FDT, but not with that using SAP. In another study, temporal RNFL thickness measured by Heidelberg retina tomography (HRT) had a weak correlation with MS in the corresponding VF area in FDT and SAP.…”

Section: Discussionsupporting

confidence: 91%

“…In glaucoma patients with peripheral scotoma, the overall structure–function relationship was similar between SAP and FDT in this study corresponding to the study of Pinto et al 39 in which correlations between RNFL thickness and MS measured in dB were similar for SAP and the FDT.…”

Section: Discussionsupporting

confidence: 88%

“…Poor correlations were found previously in the temporal sector between RNFL thickness measured using Spectralis OCT and the VF sensitivity measured using SAP in the corresponding area. 39 In one study investigating the structure–function relationship using scanning laser polarimetry and SAP in glaucoma patients, the strongest correlation was shown in the superotemporal sector, followed by inferotemporal sectors, while the temporal sector showed no statistically significant results. 40 In another study evaluating structure–function relationships using SD-OCT, weak correlations were detected between temporal RNFL thickness and the corresponding VF areas.…”

Section: Discussionmentioning

confidence: 99%

“…In FDT matrix perimetry, sensitivities are expressed as the dB [20 × log(1/Michelson contrast)]. 38,39 Global and sectoral MS were evaluated on threshold printout in VF tests. Global MS is calculated as the mean of VF sensitivities in 52 points and sectoral MS as those in the sectors according to the structure–function correspondence map suggested by Garway-Heath et al 37 (Fig.…”

Section: Methodsmentioning

confidence: 99%

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Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Jung

Kang

Choi

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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PurposeWe evaluated whether the structure–function relationship in glaucoma patients with parafoveal scotoma or peripheral scotoma differs with the use of frequency doubling technology (FDT) or short-wavelength automated perimetry (SWAP) compared to standard automated perimetry (SAP).MethodsGlaucoma patients with isolated parafoveal scotoma (PFS) within the central 10° of fixation in 1 hemifield and those with an isolated peripheral nasal step (PNS) within the nasal periphery outside 10° of fixation in one hemifield were studied. Peripapillary retinal nerve fiber layer (RNFL) thickness was measured using spectral-domain optical coherence tomography. The topographic relationships between structure and function were investigated.ResultsIn the PNS group, superotemporal (r2 = 0.300, P = 0.001) and inferotemporal (r2 = 0.302, P = 0.001) RNFL thickness showed significant correlations with the corresponding visual field (VF) sensitivity using linear regression model in SAP. In the PFS group, temporal RNFL thickness was not correlated with nasal mean sensitivity (MS) on SAP (r2 = 0.103, P = 0.065). Using FDT, however, the temporal RNFL thickness was correlated with nasal MS in the PFS group (r2 = 0.277, P = 0.001). Using SWAP, the temporal RNFL thickness was not significantly associated with regional VF sensitivity in the PFS group (r2 = 0.052, P = 0.192).ConclusionsIn glaucoma with peripheral scotoma, the RNFL thickness was associated significantly with the corresponding VF loss in SAP, FDT, and SWAP. In eyes with PFS, however, the topographic structure–function relationships were not distinct with SAP or SWAP. Frequency doubling technology performed well in terms of structure–function correlation in glaucoma with PFS.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Jung

Kang

Choi

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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“…6,12,13,21,25,38 This cutoff value was estimated to be the asymptotic point and was determined by simple visual inspection of the curve of the relationship between RNFL and SAP. While the SLR method used herein roughly agreed with Hood and Kardon's predictions with regard to the asymptotic point, it also showed that the asymptotic point may be variable, which confirms our recent findings.…”

mentioning

confidence: 99%

Residual and Dynamic Range of Retinal Nerve Fiber Layer Thickness in Glaucoma: Comparison of Three OCT Platforms

Mwanza

Kim

Budenz

et al. 2015

Invest. Ophthalmol. Vis. Sci.

122

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PURPOSE. To estimate visual field (VF) sensitivity at which retinal nerve fiber layer (RNFL) thinning reaches the measurement floor and at which RNFL stops thinning (change points), the dynamic range of RNFL thickness, and the number of steps from normal to RNFL floor among three optical coherence tomography (OCT) devices. METHODS.Glaucomatous patients (n ¼ 58) and healthy subjects (n ¼ 55-60) prospectively underwent VF testing and RNFL thickness measurement with Cirrus, Spectralis, and RTVue. Change points and corresponding RNFL thicknesses were estimated with simple linear regression (SLR) and Bayesian change point (BCP) analyses. The dynamic range and number of steps to RNFL floor were determined.RESULTS. The average VF change points and corresponding residual thickness at the time RNFL stopped thinning were À22.2 dB and 57.0 lm (Cirrus), À25.3 dB and 49.2 lm (Spectralis), and À24.6 dB and 64.7 lm (RTVue). The RNFL dynamic ranges derived from SLR values were wider on Spectralis (52.6 lm) than on Cirrus (35.4 lm) and RTVue (35.5 lm); the corresponding number of steps to reach the RNFL floor were 9.0 on Cirrus, 10.6 on Spectralis, and 8.3 on RTVue.CONCLUSIONS. The relative VF sensitivity at which average RNFL thickness reaches the measurement floor, the residual layer thickness, and RNFL dynamic measurement range differ among the three devices. However, the number of steps from normal to the RNFL thickness floor is comparable.

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Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

et al. 2015

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Structure–Function Correlations in Glaucoma Using Matrix and Standard Automated Perimetry Versus Time-Domain and Spectral-Domain OCT Devices

Abstract: The FDT matrix and SAP visual sensitivities were related strongly to the RNFL thickness measured with the Stratus and Spectralis OCT devices, particularly in the overall and arcuate sectors.

Cited by 26 publications

References 29 publications

Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Structure–Function Relationship in Glaucoma Patients With Parafoveal Versus Peripheral Nasal Scotoma

Residual and Dynamic Range of Retinal Nerve Fiber Layer Thickness in Glaucoma: Comparison of Three OCT Platforms

Predicted and Measured Retinal Nerve Fiber Layer Thickness From Time-Domain Optical Coherence Tomography Compared With Spectral-Domain Optical Coherence Tomography

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