Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides

Among peptide‐based drugs, naturally occurring bicyclic compounds have been established as molecules with unique therapeutic potential. The diverse pharmacological activities associated with bicyclic peptides from marine tunicates, sponges, and bacteria render them suitable to be employed as effective surrogate between complex and small therapeutic moieties. Bicyclic peptides possess greater conformational rigidity and higher metabolic stability as compared with linear and monocyclic peptides. The antibody‐like affinity and specificity of bicyclic peptides enable their binding to the challenging drug targets. Bridged macrobicyclic peptides from natural marine resources represent an underexplored class of molecules that provides promising platforms for drug development owing to their biocompatibility, similarity, and chemical diversity to proteins. The present review explores major marine‐derived bicyclic peptides including disulfide‐bridged, histidinotyrosine‐bridged, or histidinoalanine‐bridged macrobicyclic peptides along with their structural characteristics, synthesis, structure–activity relationship, and bioproperties.The comparison of these macrobicyclic congeners with linear/monocyclic peptides along with their therapeutic potential are also briefly discussed.

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“…Also, several macrolides including swinholide A, I, and hurghadolide A are reported from Red Sea T. swinhoei . [ 41–45 ]…”

Section: Bioactive Bridged Macrobicyclic Peptides From Marine Spongesmentioning

confidence: 99%

Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources

Dahiya

Kumar

et al. 2021

Archiv der Pharmazie

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“…Marine proteins contain peptides with various biological activities including antihypertensive, antiobesity, antioxidant, antimicrobial, immunomodulatory, and anticancer properties [158][159][160]. Pacific cod (Gadus macrocephalus) skin gelatin appears to be a potential source for the production of multifunctional peptides when hydrolyzed by proteolytic enzymes.…”

Section: Marine-derived Peptidesmentioning

confidence: 99%

Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome

Jahandideh

2020

IJMS

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In addition to the regulation of blood pressure, the renin-angiotensin system (RAS) also plays a key role in the onset and development of insulin resistance, which is central to metabolic syndrome (MetS). Due to the interplay between RAS and insulin resistance, antihypertensive compounds may exert beneficial effects in the management of MetS. Food-derived bioactive peptides with RAS blocking properties can potentially improve adipose tissue dysfunction, glucose intolerance, and insulin resistance involved in the pathogenesis of MetS. This review discusses the pathophysiology of hypertension and the association between RAS and pathogenesis of the MetS. The effects of bioactive peptides with RAS modulating effects on other components of the MetS are discussed. While the in vivo reports on the effectiveness of antihypertensive peptides against MetS are encouraging, the exact mechanism by which these peptides infer their effects on glucose and lipid handling is mostly unknown. Therefore, careful design of experiments along with standardized physiological models to study the effect of antihypertensive peptides on insulin resistance and obesity could help to clarify this relationship.

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“…Bioactive peptide from marine organism reported have wide biological potential as antihypertensive, antioxidant, antidiabetic, and anticancer. It was also recorded that bioactive peptides highly potential as therapeutic drugs in the treatment of heart, blood vessel disease and diabetes, formulated in functional food [45]. Some bioactive peptides have been reviewed as anticancer found in several marine organisms such as sponges, mollusks, fish and other marine organisms including sea cucumbers.…”

Section: Peptide Potential Of Sea Cucumber As Anticancermentioning

confidence: 99%

The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review

Wulandari

Syahputra

Putra

2020

J. Pure App. Chem Res

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The extreme development and resistance towards cancer drugs, and also the high toxicity, drug resistance and side effects of cancer chemotherapy drug triggers us to develop new drugs as one of the alternative substitutes or combinations of cancer drugs, one of the resources come from marine biodiversity especially sea cucumber. The bioactive compound from sea cucumber can inhibit cancer cell growth with the various mechanism. This study aims to analyze chemical composition, bioactive compound from sea cucumber to inhibit cancer cell line and to analyze mechanism of action of sea cucumber as anticancer with the most recent research studies. The result shows sea cucumber contained protein 44-82%, amino acid, fatty acid, collagen, peptide, micro essential. Each sea cucumber species produced the different secondary metabolites that can use as anticancer. Sea cucumbers contain triterpene glycosides, saponins, holothurin A, stichoposides, frondoside, cucumariosides, dsechinoside, fucoidan, triterpenoid aglycones (philinopgeni), non-glycosaminoglycan, sulfated glycans, sulfated polysaccharides, non-glycosaminosides) that can inhibit cancer cell line. Those bioactive compounds have a various mechanism such as apoptosis in cell line and mitochondria, antioxidative mechanism and membranolytic.

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Structure, Function, and Therapeutic Potential of Marine Bioactive Peptides

Abstract: In recent years, bioactive peptides from marine organisms have gained increasing attention in the field of pharmaceutical, cosmeceutical, and nutraceutical product development owing to their interesting biological properties [...]

Cited by 20 publications

References 28 publications

Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources

Structural and biological aspects of natural bridged macrobicyclic peptides from marine resources

Perspectives on the Potential Benefits of Antihypertensive Peptides towards Metabolic Syndrome

The Bioactive Compound and Mechanism of Action of Sea Cucumber (Holothuridae) as Anticancer: A Review

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