Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels

Gribkoff, Valentin K.; Kaczmarek, Leonard K.

doi:10.1002/9780470429907

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Cited by 4 publications

References 63 publications

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Computational Methods and Algorithms to Segment and Model Recurrent Bursting Events in Long-Time Series Springer Nature Book about Neuromethods

Zonca,

Dossi,

Rouach

et al. 2024

Neuromethods

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Computational Methods and Algorithms to Segment and Model Recurrent Bursting Events in Long-Time Series Springer Nature Book about Neuromethods

Zonca,

Dossi,

Rouach

et al. 2024

Neuromethods

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Saccharomyces cerevisiae as a model for the evaluation of dihydropyridine calcium antagonist effects

2014

Int. J. Biosci.

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In this work, we are interested to using Saccharomyces cerevisiae as eukaryotic model and an alternative one to animal testing for bringing out the effect of nifedipine, a dihydropiridine L-type calcium channel blocker. Thus, a culture of Saccharomyces cerevisiae was treated with different concentrations of this xenobiotic (0.01, 0.05, 0.5, 1 mM) during 3 hours. After that we measured the levels of some stress biomarkers (GSH, GST and peroxidases activities). The results obtained show a significant/high significant increase in all studied biomarkers following treatment with a dose-response manner. These data highlight an oxidative stress induced by the presence of the calcium antagonist, and expressed by a stimulation of the oxidative enzymes activities

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Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential

Du¹,

Gamper²

2013

110

103

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Electrical excitation of peripheral somatosensory nerves is a first step in generation of most pain signals in mammalian nervous system. Such excitation is controlled by an intricate set of ion channels that are coordinated to produce a degree of excitation that is proportional to the strength of the external stimulation. However, in many disease states this coordination is disrupted resulting in deregulated peripheral excitability which, in turn, may underpin pathological pain states (i.e. migraine, neuralgia, neuropathic and inflammatory pains). One of the major groups of ion channels that are essential for controlling neuronal excitability is potassium channel family and, hereby, the focus of this review is on the K+ channels in peripheral pain pathways. The aim of the review is threefold. First, we will discuss current evidence for the expression and functional role of various K+ channels in peripheral nociceptive fibres. Second, we will consider a hypothesis suggesting that reduced functional activity of K+ channels within peripheral nociceptive pathways is a general feature of many types of pain. Third, we will evaluate the perspectives of pharmacological enhancement of K+ channels in nociceptive pathways as a strategy for new analgesic drug design.

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Structure, Function, and Modulation of Neuronal Voltagegated Ion Channels

Cited by 4 publications

References 63 publications

Computational Methods and Algorithms to Segment and Model Recurrent Bursting Events in Long-Time Series Springer Nature Book about Neuromethods

Computational Methods and Algorithms to Segment and Model Recurrent Bursting Events in Long-Time Series Springer Nature Book about Neuromethods

Saccharomyces cerevisiae as a model for the evaluation of dihydropyridine calcium antagonist effects

Potassium Channels in Peripheral Pain Pathways: Expression, Function and Therapeutic Potential

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