Structure elucidation of two new diterpenes from Vietnamese mangrove Ceriops decandra

Abstract

Ceriops decandra (Griff.) W.Theob. (Rhizophoraceae), a true mangrove plant, occur in Africa, Australia, South Asia, and many countries of Southest Asia [1]. The bark of C. decandra is an Indian folk medicine used for the treatment of diarrhea, amoebiasis, hemorrhage, and malignant ulcers [2]. The leaf extract has been reported to exhibite antinociceptive activity [3]. Previous phytochemical investigations on this plant resulted in the isolation of lupane-and ursane-type triterpenoids from the leaf [4], beyerane-, pimarane-, kaurane-, and abietanetype diterpenoids from the roots [1, 5-7], and abietaneand podocarpane-type diterpenoids from the barks [2,8]. In an ongoing search for bioactive natural products from mangroves [9, 10], we report here the isolation, structure elucidation, and cytotoxicity assay of two new diterpenes, ceridecandrin A (1) and B (2), from C. decandra stem barks. Their structures were elucidated by analysis of HR-QTOF-MS and 1D and 2D NMR spectroscopic data. It should be noted that compound 1 is the first example of a 8,15-epoxypimarane-type diterpenoid possessing a 14,16-ether bridge, and compound 2 is the second member of a rare class of 10,19-epoxyrosane-type diterpenoid (Figure 1).

Therapeutic Potential and Ethnopharmacology of Dominant Mangroves of Bhitarkanika National Park, Odisha, India

“…Several in vitro studies signified the pragmatic activities of different mangrove extracts against human colorectal cancer, [96] breast cancer, [64,97,98] cervical cancer, [97] gastric cancer, [97] liver cancer, [81] skin cancer, [83] lung cancer, [99] and leukaemia. [43] Diverse phytochemicals with potential anticancer and cytotoxic activities were also isolated time to time from A. corniculatum, [100,101] A. marina, [41,102] C. decandra [103] and E. agallocha. [104]…”