Structure, Diversity, and Ionic Permeability of Neuronal and Muscle Acetylcholine Receptors

Dani, John A.

doi:10.1007/978-3-0348-7327-7_3

Cited by 10 publications

(10 citation statements)

References 80 publications

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“…Apart from α-helix 2 the linker between the α1 and α2-helices is also important for electrostatics and the determination of the pore size. The dimensions and shape of the pore as well as the distribution of charges correspond well to what has been predicted by Dani based on measurements of streaming potentials in the nAChR [69,103] .…”

Section: Ion Selectivitysupporting

confidence: 83%

A prokaryotic perspective on pentameric ligand-gated ion channel structure

Hilf

Dutzler

2009

Current Opinion in Structural Biology

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Section: Ion Selectivitysupporting

confidence: 83%

A prokaryotic perspective on pentameric ligand-gated ion channel structure

Hilf

Dutzler

2009

Current Opinion in Structural Biology

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“…It is evident that these protocols do not resemble the pulsatile stimulation likely found in the gland, because the frequency of APs produced by ACh cannot be experimentally controlled in a situation where continuous exposure to ACh (and to other nicotinic agonists) leads to desensitization of nicotinic receptors (18,29). The drawbacks of the ACh stimulation patterns referred to above are not present in the protocol of intermittent application of ACh puffs reported here.…”

Section: Discussionmentioning

confidence: 79%

Electrophysiological and morphological features underlying neurotransmission efficacy at the splanchnic nerve-chromaffin cell synapse of bovine adrenal medulla

Diego

2010

American Journal of Physiology-Cell Physiology

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“…The best understood example of this receptor class is the nicotinic acetylcholine receptor (nAChR), especially the receptor present at high densities in Torpedo Marmorata ray electroplax (Briley and Changeux 1977). This receptor is closely related in structure to mammalian nAChRs Dani 1993;Karlin 1993;Galzi and Changeux 1995). Many of the features of this receptor will be used to illustrate general structural properties of neurotransmitter-gated ion channels in this review.…”

Section: General Features Of Neurotransmitter-gated Ion Channelsmentioning

confidence: 99%

“…One notable feature of the neuronal α-bungarotoxin sensitive receptors is the high calcium permeability of their channels. Several subunits for mammalian muscle and neuronal nAChRs have subsequently been cloned (Dani 1993;Karlin 1993;Galzi and Changeux 1995).…”

Section: General Features Of Neurotransmitter-gated Ion Channelsmentioning

confidence: 99%

Alcohols and neurotransmitter gated ion channels: past, present and future

Lovinger

1997

Naunyn-Schmiedeberg's Arch Pharmacol

163

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The neurotransmitter-gated ion channels form a superfamily of neurotransmitter receptors specialized for recognizing transmitters and rapidly gating ion channels that are contained within the same holoprotein complex. A large body of research indicates that alcohols alter the function of this class of receptor at concentrations relevant to the intoxicating and anesthetic effects of the alcohols. In addition, studies have implicated several types of neurotransmitter-gated channels in intoxicating and anesthetic alcohol actions. All of the neurotransmitter-gated ion channels contain conserved features such as N-terminal ligand binding domains, hydrophobic membrane spanning domains and charged pore-lining domains. However, at least two, and possibly three families of receptors have been identified within the superfamily, including the nicotinic ACh-like receptors, the ionotropic glutamate receptors and the ATP-gated ion channels. This review will begin with a brief overview of the structural features of the different receptors, with an emphasis on comparing and contrasting features of the different families of neurotransmitter-gated channels. The emphasis will be mostly on the nicotinic-like receptors and the iGluRs, since more is known about these receptors than about other types of ligand-activated cation channels. The remainder of the review focuses on the latest studies aimed at determining the mechanism of alcohol actions on this superfamily of receptor-channels as well as the relationship between the molecular structure of these channels and the effects of alcohols on channel function. In addition, emerging directions for future study of these effects of alcohols and possible regions of the protein that may be altered during alcohol exposure are discussed.

show abstract

Structure, Diversity, and Ionic Permeability of Neuronal and Muscle Acetylcholine Receptors

Cited by 10 publications

References 80 publications

A prokaryotic perspective on pentameric ligand-gated ion channel structure

A prokaryotic perspective on pentameric ligand-gated ion channel structure

Electrophysiological and morphological features underlying neurotransmission efficacy at the splanchnic nerve-chromaffin cell synapse of bovine adrenal medulla

Alcohols and neurotransmitter gated ion channels: past, present and future

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