Structure determination of terpenes by the crystalline sponge method

Abstract

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Applying the Crystalline Sponge Method to Agrochemicals: Obtaining X-ray Structures of the Fungicide Metalaxyl-M and Herbicide S-Metolachlor

“…Encapsulation times ranging from 53 to 90 days would not be acceptable for use in a routine analytical technique used in an academic or industrial setting, such as in the agrochemical research industry. The time required for guest inclusion in the CSM is typically a great deal shorter than those reported here for the encapsulation of guests D and E ; these range from a day to a few weeks. ,,,− Increasing the temperature at which the encapsulation was performed to 50 °C vastly reduced the time required for the encapsulation of D and E to times that were closer to those observed in other guest encapsulations reported in the literature. ,,,− …”

“…The time required for guest inclusion in the CSM is typically a great deal shorter than those reported here for the encapsulation of guests D and E ; these range from a day to a few weeks. 17 , 19 , 32 , 39 − 41 Increasing the temperature at which the encapsulation was performed to 50 °C vastly reduced the time required for the encapsulation of D and E to times that were closer to those observed in other guest encapsulations reported in the literature. 17 , 19 , 32 , 39 − 41 …”

Advanced crystallisation methods for small organic molecules

“…63,69 Following the successful work with triphenylene, the crystalline sponge method has been applied to the structural determination by SCXRD of over 60 host-guest systems to date. 39,67,[72][73][74][75][76][77][78][79][80][81][82][83] Additionally, crystalline sponges have been used in combination with chromatographic separation techniques (HPLC 39 and GC 84 ), characterisation of drug metabolites, 85 and organometallic compounds. 86…”

Applications of the crystalline sponge method and developments of alternative crystalline sponges

“…This study of guest-host interaction was then expanded and the effect of systematic changes in guest size and functionality was observed as the change in orientation and ordering of guests within the framework. 88 In 2020, Carmalt et al 89 determined the structures of terpenes, such as β-damascone…”