Structure-Dependent Activity of Plant-Derived Sweeteners

Ҫiçek, Serhat Sezai

doi:10.3390/molecules25081946

Cited by 19 publications

(14 citation statements)

References 93 publications

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“…At least 50 patents for the chemical synthesis, extraction and use of HE as a non‐caloric sweetener have emerged so far, however, the scalable production of HE is still a challenge [3] . HE is still considered as a lead compound for the synthesis of related derivatives such as (+)‐4β‐hernandulcin which presents sweeter taste than HE as well as better solubility in water [4] . It is known that the essential oil of P. scaberrima shows a wide range of biological activities, including analgesic and antispasmodic properties based on its anti‐cholinergic and anti‐histaminergic action [5] .…”

Section: Introductionmentioning

confidence: 99%

Hernandulcin Production in Cell Suspensions of Phyla Scaberrima: Exploring Hernandulcin Accumulation through Physical and Chemical Stimuli

Villa‐Ruano

Castro-Juárez

Lozoya‐Gloria

et al. 2021

Chemistry & Biodiversity

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Hernandulcin (HE) is a non‐caloric sweetener synthesized by the Mexican medicinal plant Phyla scaberrima. Herein we present the results of HE production through cell suspensions of P. scaberrima as well as the influence of pH, temperature, biosynthetic precursors and potential elicitors to enhance HE accumulation. The incorporation of mevalonolactone (30–400 mg L−1) farnesol (30–400 mg L−1), AgNO3 (0.025–0.175 M), cellulase (5–60 mg L−1; 0.3 units/mg), chitin (20–140 mg L−1) and (+)‐epi‐α‐bisabolol (300‐210 mg L−1) to the cell suspensions, resulted in a differential accumulation of HE and biomass. Among elicitors assayed, chitin, cellulase and farnesol increased HE production from 93.2 to ∼160 mg L−1 but, (+)‐epi‐α‐bisabolol (obtained by a synthetic biology approach) increased HE accumulation up to 182.7 mg L−1. HE produced by the cell suspensions was evaluated against nine strains from six species of gastrointestinal bacteria revealing moderate antibacterial activity (MIC, 214–465 μg mL−1) against Staphylococcus aureus, Escherichia coli and Helicobacter pylori. Similarly, HE showed weak toxicity against Lactobacillus sp. and Bifidobacterium bifidum (>1 mg mL−1), suggesting a selective antimicrobial activity on some species of gut microbiota. According to our results, chitin and (+)‐epi‐α‐bisabolol were the most effective molecules to enhance HE accumulation in cell suspensions of P. scaberrima.

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Section: Introductionmentioning

confidence: 99%

Hernandulcin Production in Cell Suspensions of Phyla Scaberrima: Exploring Hernandulcin Accumulation through Physical and Chemical Stimuli

Villa‐Ruano

Castro-Juárez

Lozoya‐Gloria

et al. 2021

Chemistry & Biodiversity

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“…Siraitia grosvenorii (Swingle) C. Jeffery, Luohanguo S. grosvenorii (Cucurbitaceae) is native to parts of China and Thailand. The fruits contain cucurbitane triterpenes named mogrosides, possessing a sweetening potency that is up to 500 times higher than that of sucrose [1,2]. For S. grosvenorii, a rise in market value is expected despite the existing difficulties with the culture.…”

Section: Plantsmentioning

confidence: 99%

Culturing Important Plants for Sweet Secondary Products under Consideration of Environmentally Friendly Aspects

2022

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Some sweet tasting plant secondary metabolites are non-caloric or low nutritive compounds that have traditional use in food formulations. This mini-review focuses on conventional and advanced cultivation regimes of plants that accumulate sweet tasting or sweet taste modulating secondary metabolites of potential economic importance, in particular mogrosides (Siraitia grosvenorii), phyllodulcin (Hydrangea macrophylla), glycyrrhizin (Glycyrrhiza glabra), steviol glycosides (Stevia grosvenorii), and rubusoside (Rubus suavissimus). Consequential obstacles during the cultivation of Hydrangea macrophylla cultivars outside their natural habitat in a protected cultivation environment are addressed. Culturing at non-habitat locations facilitates short transportation routes of plant material for processing, which can be a key to an economically and environmentally compatible usage. The biosynthetic pathways, as far as known, are shortly mentioned. The proved or hypothetical degradation pathways of the compounds to minimalize environmental contamination are another focal point.

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“…Currently, isolated natural products capture a lot of attention for ‘lead compound’ selection in the primary stage of drug discovery, where the SAR analysis plays a vital role in describing the structural configuration connected with biological activity and potential mechanisms of action [ 143 , 144 ]. For H. pubescens , the most common steroidal-alkaloid class of phytoconstituents; conarrhimine, conessimine, conessine, conimine and isoconnessine was reported to have multiple and dose-dependent biological activities.…”

Section: Pharmacologymentioning

confidence: 99%

Metabolic Diversity and Therapeutic Potential of Holarrhena pubescens: An Important Ethnomedicinal Plant

et al. 2020

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Holarrhena pubescens is an important medicinal plant of the Apocynaceae family that is widely distributed over the Indian subcontinent. The plant is extensively used in Ayurveda and other traditional medicinal systems without obvious adverse effects. Beside notable progress in the biological and phytochemical evaluation of this plant over the past few years, comprehensive reviews of H. pubescens are limited in scope. It has economic importance due to the extensive use of seeds as an antidiabetic. Furthermore, the plant is extensively reported in traditional uses among the natives of Asia and Africa, while scientifical validation for various ailments has not been studied either in vitro or in vivo. This review aims to summarize information on the pharmacology, traditional uses, active constituents, safety and toxicity of H. pubescens. Chemical analysis of H. pubescens extracts revealed the presence of several bioactive compounds, such as conessine, isoconnessine, conessimine, conimine, conessidine, conkurchicine, holarrhimine, conarrhimine, mokluangin A-D and antidysentericine. Overall, this review covers the ethnopharmacology, phytochemical composition, and pharmacological potential of H. pubescens, with a critical discussion of its toxicity, biological activities (in vitro and in vivo), the mechanism of action, as well as suggestions for further basic and clinical research.

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Structure-Dependent Activity of Plant-Derived Sweeteners

Cited by 19 publications

References 93 publications

Hernandulcin Production in Cell Suspensions of Phyla Scaberrima: Exploring Hernandulcin Accumulation through Physical and Chemical Stimuli

Hernandulcin Production in Cell Suspensions of Phyla Scaberrima: Exploring Hernandulcin Accumulation through Physical and Chemical Stimuli

Culturing Important Plants for Sweet Secondary Products under Consideration of Environmentally Friendly Aspects

Metabolic Diversity and Therapeutic Potential of Holarrhena pubescens: An Important Ethnomedicinal Plant

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