Structure characterization, modification through carboxymethylation and sulfation, and in vitro antioxidant and hypoglycemic activities of a polysaccharide from Lachnum sp.

Wang, Yufen; Hou, Guohua; Li, Jinglei; Surhio, Maheen Mahwish; Ye, Ming

doi:10.1016/j.procbio.2018.06.002

Cited by 50 publications

(20 citation statements)

References 45 publications

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“…The absorption peaks at 1400.7 and 1608.3 cm –1 were attributed to the C–O stretching vibration and the CO asymmetric stretching vibration of −COOH, respectively, which were low in CSP0. The absorption peak at 1027.3 cm –1 corresponded to the stretching vibration of the pyranose ring of the glucose residue …”

Section: Resultsmentioning

confidence: 99%

“…The absorption peak at 1027.3 cm −1 corresponded to the stretching vibration of the pyranose ring of the glucose residue. 37 Compared with CSP0 (1608.3 and 1400.7 cm −1 ), the absorption peak positions of the three CCSPs modified by carboxymethylation were red-or blue-shifted. The asymmetric stretching vibration of CO was red-shifted from 1608.3 to 1599.3, 1598.8, and 1598.8 cm −1 .…”

Section: Preparation and Characterization Of Ccspsmentioning

confidence: 89%

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Carboxymethylation of Corn Silk Polysaccharide and Its Inhibition on Adhesion of Nanocalcium Oxalate Crystals to Damaged Renal Epithelial Cells

Zou

Huang

Sun

et al. 2021

ACS Biomater. Sci. Eng.

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The purpose of this study was to explore the repair effect of carboxymethyl-modified corn silk polysaccharide (CSP) on oxidatively damaged renal epithelial cells and the difference in adhesion between cells and calcium oxalate crystals. The CSP was degraded and modified through carboxymethylation. An oxidatively damaged cell model was constructed by oxalate damage to human kidney proximal tubular epithelial (HK-2) cells. Then, the damaged cells were repaired by modified polysaccharides, and the changes in biochemical indexes and adhesion ability between cells and crystals before and after repair were detected. Four modified polysaccharides with carboxyl group (−COOH) contents of 3.92% (CSP0), 7.75% (CCSP1), 12.90% (CCSP2), and 16.38% (CCSP3) were obtained. Compared with CSP0, CCSPs had stronger antioxidant activity, could repair damaged HK-2 cells, and could reduce phosphorylated serine eversion on the cell membrane, the expression of osteopontin (OPN) and Annexin A1, and crystal adhesion. However, its effect on the expression of hyaluronic acid synthase was not substantial. The carboxymethyl modification of the CSP can improve its ability to repair cells and inhibit crystal adhesion and aggregation. A high carboxymethylation degree results in strong polysaccharide activity. CCSPs are expected to reduce the risk of kidney stone formation and recurrence.

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Section: Resultsmentioning

confidence: 99%

Section: Preparation and Characterization Of Ccspsmentioning

confidence: 89%

Carboxymethylation of Corn Silk Polysaccharide and Its Inhibition on Adhesion of Nanocalcium Oxalate Crystals to Damaged Renal Epithelial Cells

Zou

Huang

Sun

et al. 2021

ACS Biomater. Sci. Eng.

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“…The ATR-FT-IR spectra exhibited absorption bands at 2918, 1416, 1371, and 1234 cm À 1 , which are typical bands for carbohydrates. [17] 1148, 1077 and 1015 cm À 1 were the absorption of pyranoside. 850 cm À 1 was attributed to C/H deformation vibration of α pyranose, which indicated NPPN was an α pyranoside.…”

Section: Infrared Spectrum Analysismentioning

confidence: 99%

Structural Characterization of Polysaccharides Isolated from Panax notoginseng Medicinal Residue and Its Protective Effect on Myelosuppression Induced by Cyclophosphamide

Liu

et al. 2021

Chemistry & Biodiversity

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This study aims to establish the isolation and purification method of polysaccharides from medicinal residue of Panax notoginseng (PPN). The structure and protective effect of PPN on myelosuppression mice were investigated. One neutral polysaccharide (NPPN) and five acidic polysaccharides (APPN I, APPN II-A, APPN II-B, APPN III-A, and APPN III-B) were obtained. The results confirmed that NPPN, APPN I and APPN II-A are glycan with 1, 4 main chains. APPN III-A is a glycan. APPN II-B and APPN III-B are homogalacturonan pectin with 1, 4 main chains. This study demonstrated that NPPN played a bone marrow protective role in myelosuppression mice induced by cyclophosphamide. NPPN could relieve cell cycle arrest, reduce the apoptosis rate of marrow cells, and improve granulocyte-macrophage colony-stimulating (GM-CSF), thermoplastic polyolefin (TPO) and erythropoietin (EPO) serum level, which contributes to promoting the proliferation of hematopoietic cells.

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“…The α-amylase inhibitory activity was detected by a previously reported method (Wang et al, 2018). Acarbose was used as a positive control.…”

Section: α-Amylase Inhibitory Activitymentioning

confidence: 99%

“…The main source of blood sugar was dietary carbohydrates hydrolyzed by α-amylase and α-glucosidase (Wang et al, 2018). Therefore, by inhibiting the activity of α-amylase and α-glycosidase, postprandial blood sugar can be effectively reduced, so as to achieve the purpose of treating diabetes (Paun et al, 2016;Paun et al, 2020).…”

Section: Inhibitory Effects Of α-Amylase and α-Glucosidasementioning

confidence: 99%

Effects of different extraction methods on the structure, antioxidant activity, α‐amylase, and α‐glucosidase inhibitory activity of polysaccharides from Potentilla discolor Bunge

Zheng

Chen

Yang

et al. 2021

J. Food Process. Preserv.

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Potentilla discolor Bunge is commonly found in the North Temperate Zone and has a long history of clinical application in Chinese medicine. Potentilla discolor Bunge could effectively treat diarrhea, malaria, hemoptysis, hematemesis, ringworm, and many other diseases (Zhang et al., 2010). Recently, it was found that the whole herb of Potentilla discolor Bunge has antioxidant and anti-inflammatory activities, besides it can lower blood glucose and protect pancreatic β-cells against type 2 diabetes (Tomczyk & Latte, 2009). The main bioactive compounds in Potentilla discolor Bunge include flavonoids, triterpenoids, alkaloids, polysaccharides, oil, etc., especially polysaccharide active compounds (Cheng et al., 2020;Wang et al., 2019;Zhang et al., 2018). However, the mechanism of its bioactivities has not been fully understood so far. Thus, it is of great importance to reveal the bioactive ingredients in Potentilla discolor Bunge.Polysaccharides are macromolecular compounds extracted from plants, animals, and microorganisms, which are formed by polymerization of multiple monosaccharides or their derivatives (Xie et al., 2016). Recently, the excellent bioactivities of plant polysaccharides have attracted increasing attention, such as antioxidant activity, hypoglycemic activity (Chen et al., 2018), hepatoprotective

show abstract

Structure characterization, modification through carboxymethylation and sulfation, and in vitro antioxidant and hypoglycemic activities of a polysaccharide from Lachnum sp.

Cited by 50 publications

References 45 publications

Carboxymethylation of Corn Silk Polysaccharide and Its Inhibition on Adhesion of Nanocalcium Oxalate Crystals to Damaged Renal Epithelial Cells

Carboxymethylation of Corn Silk Polysaccharide and Its Inhibition on Adhesion of Nanocalcium Oxalate Crystals to Damaged Renal Epithelial Cells

Structural Characterization of Polysaccharides Isolated from Panax notoginseng Medicinal Residue and Its Protective Effect on Myelosuppression Induced by Cyclophosphamide

Effects of different extraction methods on the structure, antioxidant activity, α‐amylase, and α‐glucosidase inhibitory activity of polysaccharides from Potentilla discolor Bunge

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