Structure, Biological Activity and Synthesis of Polyamine Analogues and Conjugates

Synthesis, nucleic acid binding and cytotoxicity of polyethyleneimine-copper(II) complexes containing 1,10-phenanthroline and l-valine

“…Incorporation of more than one copper centre in a single polymer chain produces enhanced electrostatic interactions to the anionic nucleic acid phosphate backbone [24]. Polyamine compounds are often based on their polycationic nature at physiological pH because in that environment, they are known to play an essential role for many biological processes [25]. Polyethyleneimine, (PEI), possesses quite a number of advantages as polymer chelating agent, such as good water solubility, high content of functional groups, suitable molecular weights as well as good physical and chemical stabilities [26].…”

Self-assembly in lanthanum(III) and calcium(II) complexes of salicylaldimines derived from putrescine

“…The application of lanthanide complexes as radiopharmaceuticals and therapeutic agents in the treatment of inflammation, arthritis and atherosclerosis is based on the ability of lanthanide ions to antagonize calcium-dependent processes [1][2][3][4][5][6][7][8][9][10][11]. Among the chemical moieties which have been used as part of potential catalysts and chemotherapeutic agents are biogenic polyamines: putrescine, spermidine, spermine and their synthetic analogs [12][13][14]. The incorporation of biogenic polyamine fragments with flexibility and * Corresponding author.…”

Ferrocenylthiosemicarbazones conjugated to a poly(propyleneimine) dendrimer scaffold: Synthesis and in vitro antimalarial activity

“…In addition, polyamines are involved in diverse biological processes including cell proliferation and differentiation, regulation of gene expression, translation, modulation of cell signalling and membrane stabilization [1,8,9]. Recently, an array of synthetic polyamines and conjugates has attracted considerable attention for pharmaceutical application [10]. A significant number of symmetrical and asymmetrical linear alkyl polyamines, as well as drugpolyamine conjugates, have been evaluated for potential antitumour activity [11].…”