Abstract:Human osteoclast-stimulating factor (OSF) induces osteoclast formation and bone resorption in senile osteoporosis by recruiting multiple signaling complexes with cognate interacting partners through its N-terminal Src homology 3 (SH3) peptide-recognition domain. The domain can recognize and bind to the polyproline regions of its partner proteins, rendering a broad ligand specificity and cross-reactivity. Here, the structural basis and physicochemical property of peptide affinity and cross-reactivity to OSF SH3… Show more
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