Structure-based optimization of salt-bridge network across the complex interface of PTPN4 PDZ domain with its peptide ligands in neuroglioma

Xiao, Xian Bin; He, Qiang-Hua; Yu, L.; Wang, Songqing; Li, Yang; Yang, Hua; Zhang, Aihua; Ma, Xiaojing; Peng, Yujie; Chen, Bing

doi:10.1016/j.compbiolchem.2016.11.005

Cited by 2 publications

(3 citation statements)

References 27 publications

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“…Subsequent studies revealed that the PTPN4 PDZ domain in fact auto-inhibits the enzyme’s catalytic activity, and this is abrogated upon binding of a PDZ domain ligand [ 67 , 68 ]. The segment linking the PDZ and PTP domain in PTPN4 is also contributing to this regulatory principle [ 69 , 70 ]. Thus, possibilities to interfere with PDZ-mediated PPIs represent novel routes to correct disease-related signaling processes.…”

Section: Inhibiting and Augmenting Ptp Activitiesmentioning

confidence: 99%

“…Recently, a bidentate molecule (113B7) that prevents the syntenin PDZ domain from binding targets like mutant EGFR (EGFRvIII) was shown to increase radiosensitivity and decrease growth of glioma tumors in vivo [ 154 ]. Then, there is the example of PTPN4, of which the enzyme activity is autoinhibited by its PDZ domain [ 67 , 68 , 69 , 70 ]. Upon ligand binding, the PDZ-mediated inhibition is released and PTPN4 no longer protects glioblastoma cells from apoptosis [ 66 ].…”

Section: Untying Gordian Knots In Glioblastomasmentioning

confidence: 99%

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Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases

et al. 2018

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Proper control of the phosphotyrosine content in signal transduction proteins is essential for normal cell behavior and is lost in many pathologies. Attempts to normalize aberrant tyrosine phosphorylation levels in disease states currently involve either the application of small compounds that inhibit tyrosine kinases (TKs) or the addition of growth factors or their mimetics to boost receptor-type TK activity. Therapies that target the TK enzymatic counterparts, the multi-enzyme family of protein tyrosine phosphatases (PTPs), are still lacking despite their undisputed involvement in human diseases. Efforts to pharmacologically modulate PTP activity have been frustrated by the conserved structure of the PTP catalytic core, providing a daunting problem with respect to target specificity. Over the years, however, many different protein interaction-based regulatory mechanisms that control PTP activity have been uncovered, providing alternative possibilities to control PTPs individually. Here, we review these regulatory principles, discuss existing biologics and proteinaceous compounds that affect PTP activity, and mention future opportunities to drug PTPs via these regulatory concepts.

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Section: Inhibiting and Augmenting Ptp Activitiesmentioning

confidence: 99%

Section: Untying Gordian Knots In Glioblastomasmentioning

confidence: 99%

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases

et al. 2018

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“…In the selection of the pre-load simulation circuit of the general-fed AC electronic load [3][4], due to the excellent current control strategy of the single-phase PWM rectifier circuit, it can be used to simulate a number of different load features. Hence, it has been extensively used [5][6][7][8]. The single-phase PWM rectifier is mainly composed of two key components: IGBT and DC side capacitor.…”

Section: Introductionmentioning

confidence: 99%

Fault Diagnosis of IGBT Single-Phase Bridge Arm Based on Fuzzy Logic Genetic Algorithm

2022

Teh. vjesn.

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Aiming at the problem that single-phase rectifier transformation is prone to failure in the use of three-phase rectifier transformation, this paper introduces fuzzy logic genetic algorithm into the fault detection process of IGBT single-phase bridge arm structure. The algorithm mainly analyzes the DC side current in detail in the frequency domain to judge the fault of IGBT open circuit. In the fault diagnosis of single-phase bridge arm structure, the system circuit model is analyzed by sensors by using fuzzy logic genetic algorithm to judge the type of fault. Finally, the experimental results show that this method can detect faults in a fixed sampling period and in the frequency domain. It can effectively eliminate the interference of other frequency signals and increase the reliability of the system and the accuracy of fault diagnosis.

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Structure-based optimization of salt-bridge network across the complex interface of PTPN4 PDZ domain with its peptide ligands in neuroglioma

Cited by 2 publications

References 27 publications

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases

Proteinaceous Regulators and Inhibitors of Protein Tyrosine Phosphatases

Fault Diagnosis of IGBT Single-Phase Bridge Arm Based on Fuzzy Logic Genetic Algorithm

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