Structure-based mechanism of RyR channel operation by calcium and magnesium ions
Alexandra Zahradníková,
Jana Pavelková,
Miroslav Sabo
et al.
Abstract:Ryanodine receptors (RyRs) serve for excitation-contraction coupling in skeletal and cardiac muscle cells in a noticeably different way, not fully understood at the molecular level. We addressed the structure of skeletal (RyR1) and cardiac (RyR2) isoforms relevant to the gating by divalent ions (M2+). The bioinformatics analysis of 43 cryo-EM RyR structures ascertained the EF1 and EF2 loops as a moderate-affinity non-specific M2+binding site interacting with the S23 loop of neighbor monomer stronger in RyR1 th… Show more
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