Structure-based design and parallel synthesis of N-benzyl isatin oximes as JNK3 MAP kinase inhibitors

Design, synthesis and QSAR study of certain isatin-pyridine hybrids as potential anti-proliferative agents

“…The FDA approval of sunitinib paved the way to design and synthesis of various isatin-based molecules with diverse activities against cancer. In this context, many synthetic isatin-based derivatives were developed to inhibit diverse tyrosine and serine/threonine kinases, to name just a few, c-Met kinase [10], c-Src kinase [11], RET kinase [12], FLT3 kinase [13], cyclin-dependent kinases (CDKs) [14], glycogen synthase kinase 3β (GSK-3β) [15], Aurora B kinase [16], p38α MAP kinase [17], JNK3 MAP kinase [18], p90 ribosomal S6 protein kinase 2 (RSK2) [19] and Polo-like kinase 4 (PLK4) [20,21].…”

From Anilines to Isatins: Oxidative Palladium‐Catalyzed Double Carbonylation of CH Bonds

“…N-Benzylated isatin oximes have gained much attention in the pharmaceutical industry because of their inhibitory effects of the mitogen-activated kinase JNK3. [12] The N-benzyl isatins were further transformed into the target inhibitory active N-benzyl isatin oximes in excellent yields (Scheme 3). [13] Notably, this reaction could be run on gram scale, and the desired product 2 a was obtained in 67 % yield by using 3 mol % [PdCl 2 (PPh 3 ) 2 ] [Eq.…”

Indolinones as Promising Scaffold as Kinase Inhibitors: A Review

“…Isatin oxime derivatives are among the one shown a potent and selective inhibition towards JNK family. Cao et al [96] reported a novel series of JNK-selective inhibitors based on isatin oxime. 6-methyl substituted oxime derivative of isatin (47 Fig.…”