Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites

Shin, Seong-Ah; Moon, Sun Young; Kim, Woe‐Yeon; Paek, Seung‐Mann; Park, Hyun Ho; Lee, Chang Sup

doi:10.3390/ijms19092651

Cited by 77 publications

(52 citation statements)

References 193 publications

(247 reference statements)

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“…Plant extracts are now an important source for our treatment of diseases [26,27],and many countries have invested huge amounts of money in the development of extracts to treat cancer. Paeoni orin is used as an extract of Ranunculaceae, Peony, and Purple Peony [28].The compound structure was showned in Fig.…”

Section: Discussionmentioning

confidence: 99%

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

yongan¹,

Yu²,

Li³

et al. 2020

Preprint

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In the synthesis of chemical drugs used to treat various cancers and tumors,more and more scientists are now focusing on the development of natural extracts.Paeoniflorin,as an important compounds of the total glucosides of peony,,had therapeutic effects on a variety of cancers in vivo and in vitro experiments.The purpose of this study was to use biological information analysis to reveal the basic mechanism and potential molecular mechanism of paeoniflorin treatment.We evaluated the efficacy of paeoniflorin through Traditional Chinese Medicine Systems Pharmacology Database(TCMSP).The potential targets of paeoniflorin were identified and summarized by Comparative Toxicogenomics Database (CTD),and GeneMANIA protein interaction analysis was performed online.Also.We used WebGestalt for Gene Ontology(GO) analysis and Kyoto Encyclopedia of Genes and Genomes(KEGG) analysis and functional annotation.Finally,cytoscape was used to construct the paeoniflorin-target-pathway network to predict the results.

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Section: Discussionmentioning

confidence: 99%

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

yongan¹,

Yu²,

Li³

et al. 2020

Preprint

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“…Seaweeds are specifically used to treat tumors in CHM [116]. Several studies revealed that active metabolites among the terpenoids, including carotenoids, polyphenols and alkaloids that can obtained from marine source [117][118][119][120][121][122][123][124][125]. Compounds from natural sources with antiproliferative activity represent an important and novel alternative to treat several types of cancer.…”

Section: Herbal and Non-herbal Plant Derivativesmentioning

confidence: 99%

Alternative Treatments for Cancer Prevention and Cure [Part 1]

Mohiuddin¹

2019

APCT

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Many lay people along with some so called "key opinion leaders" have a common slogan "There's no answer for cancer". Again, mistake delays proper treatment and make situation worse, more often. Compliance is crucial to obtain optimal health outcomes, such as cure or improvement in QoL. Patients may delay treatment or fail to seek care because of high out-of-pocket expenditures. Despite phenomenal development, conventional therapy falls short in cancer management. There are two major hurdles in anticancer drug development: dose-limiting toxic side effects that reduce either drug effectiveness or the QoL of patients and complicated drug development processes that are costly and time consuming. Cancer patients are increasingly seeking out alternative medicine and might be reluctant to disclose its use to their oncology treatment physicians. But there is limited available information on patterns of utilization and efficacy of alternative medicine for patients with cancer. As adjuvant therapy, many traditional medicines shown efficacy against brain, head and neck, skin, breast, liver, pancreas, kidney, bladder, prostate, colon and blood cancers. The literature reviews non-pharmacological interventions used against cancer, published trials, systematic reviews and meta-analyses.

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“…Recently, natural compounds from plants have garnered increasing attention either as potential drugs or lead compounds in drug discovery research [16,17]. The key benefits of natural compounds are the abundance of plants, compound diversity, and cost effectiveness.…”

Section: Introductionmentioning

confidence: 99%

Gigantol Targets Cancer Stem Cells and Destabilizes Tumors via the Suppression of the PI3K/AKT and JAK/STAT Pathways in Ectopic Lung Cancer Xenografts

Losuwannarak

Maiuthed

Kitkumthorn

et al. 2019

Cancers

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Lung cancer has long been recognized as an important world heath concern due to its high incidence and death rate. The failure of treatment strategies, as well as the regrowth of the disease driven by cancer stem cells (CSCs) residing in the tumor, lead to the urgent need for a novel CSC-targeting therapy. Here, we utilized proteome alteration analysis and ectopic tumor xenografts to gain insight on how gigantol, a bibenzyl compound from orchid species, could attenuate CSCs and reduce tumor integrity. The proteomics revealed that gigantol affected several functional proteins influencing the properties of CSCs, especially cell proliferation and survival. Importantly, the PI3K/AKT/mTOR and JAK/STAT related pathways were found to be suppressed by gigantol, while the JNK signal was enhanced. The in vivo nude mice model confirmed that pretreatment of the cells with gigantol prior to a tumor becoming established could decrease the cell division and tumor maintenance. The results indicated that gigantol decreased the relative tumor weight with dramatically reduced tumor cell proliferation, as indicated by Ki-67 labeling. Although gigantol only slightly altered the epithelial-to-mesenchymal and angiogenesis statuses, the gigantol-treated group showed a dramatic loss of tumor integrity as compared with the well-grown tumor mass of the untreated control. This study reveals the effects of gigantol on tumor initiation, growth, and maintain in the scope that the cells at the first step of tumor initiation have lesser CSC property than the control untreated cells. This study reveals novel insights into the anti-tumor mechanisms of gigantol focused on CSC targeting and destabilizing tumor integrity via suppression of the PI3K/AKT/mTOR and JAK/STAT pathways. This data supports the potential of gigantol to be further developed as a drug for lung cancer.

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Structure-Based Classification and Anti-Cancer Effects of Plant Metabolites

Cited by 77 publications

References 193 publications

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

Analysis of Paeoniflorin Treatment of Cancer Based on Bioinformatic Network and Potential Target Prediction

Alternative Treatments for Cancer Prevention and Cure [Part 1]

Gigantol Targets Cancer Stem Cells and Destabilizes Tumors via the Suppression of the PI3K/AKT and JAK/STAT Pathways in Ectopic Lung Cancer Xenografts

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