“…The AB loop, which forms part of the weak dimer interface, contains pathogenic variants of D18G, A19D, V20I, S23N, P24S A25T and V28M. 2, 66 Among these mutants, D18G and A25T are highly unstable and aggregation-prone. 60, 61 The observed chemical shift changes also suggest that the AB loop perturbations may propagate across the DAGH β-sheet to A109, L110 and V71, and thence to S117 in the strong dimer interface (Fig.…”