Structure–antioxidant relationships of sulfated galactomannan from guar gum

Wang, Xiaofang; Wang, Junlong; Zhang, Ji; Zhao, Baotang; Yao, Jian; Wang, Yun‐Pu

doi:10.1016/j.ijbiomac.2009.10.004

Cited by 73 publications

(39 citation statements)

References 35 publications

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“…The sulfated polysaccharides were demonstrated stronger antioxidant capacities than de-sulfated polysaccharides [33]. Also, the high degree of sulfation and low molecular weight showed the best antioxidant capacities [34].…”

Section: Discussionmentioning

confidence: 92%

In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

Matloub¹,

El‐Senousy²,

El-Sayed³

et al. 2017

APJTD

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Section: Discussionmentioning

confidence: 92%

In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

Matloub¹,

El‐Senousy²,

El-Sayed³

et al. 2017

APJTD

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“…For sulfated polysaccharides, the degree of substitution and position of sulfated groups are also important [6]. There are many reports demonstrating that sulfation improves the biological activity of polysaccharides, including anti-coagulant [7], antiviral [8], immunostimulant [9], hypoglycemic [10], anti-oxidant [11], cytotoxic [12, 13], and antitumor [14] properties.…”

Section: Introductionmentioning

confidence: 99%

Characterization and cytotoxic activity of sulfated derivatives of polysaccharides from Agaricus brasiliensis

Cardozo

Camelini

Cordeiro

et al. 2013

International Journal of Biological Macromolecules

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Agaricus brasiliensis cell-wall polysaccharides isolated from fruiting body (FR) and mycelium (MI) and their respective sulfated derivatives (FR-S and MI-S) were chemically characterized using elemental analysis, TLC, FT-IR, NMR, HPLC, and thermal analysis. Cytotoxic activity was evaluated against A549 tumor cells by MTT and sulforhodamine assays. The average molecular weight (Mw) of FR and MI was estimated to be 609 and 310 kDa, respectively. FR-S (127 kDa) and MI-S (86 kDa) had lower Mw, probably due to hydrolysis occurred during the sulfation reaction. FR-S and MI-S presented ~14 % sulfur content in elemental analysis. Sulfation of samples was characterized by the appearance of two new absorption bands at 1253 and 810 cm−1 in the infrared spectra, related to S=O and C-S-O sulfate groups, respectively. Through 1H and 13C NMR analysis FR-S was characterized as a (1→6)-(1→3)-β-D-glucan fully sulfated at C-4 and C-6 terminal and partially sulfated at C-6 of (1→3)-β-D-glucan moiety. MI-S was shown to be a (1→3)-β-D-gluco-(1→2)-β-D-mannan, partially sulfated at C-2, C-3, C-4, and C-6, and fully sulfated at C-6 of the terminal residues. The combination of high degree of sulfation and low molecular weight was correlated with the increased cytotoxic activity (48 h of treatment) of both FR-S (EC50=605.6 μg/mL) and MI-S (EC50=342.1 μg/mL) compared to the non-sulfated polysaccharides FR and MI (EC50>1500 μg/mL).

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“…Approximately 80–85% of the gum is a galactomannan, which is comprised of a (1-4) β-D-mannopyranosyl backbone with branch-points from the six-position linked to single β-D-galactopyranosyl residues. [15] There are typically 1.5–2.0 mannose residues for every galactose. Guar gum galactomannans form water-dispersible hydrocolloids, which thicken when dissolved in water, leading to their use as emulsifying, thickening or stabilizing agents for a wide range of processed foods.…”

Section: Introductionmentioning

confidence: 99%

Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats

Samarghandian¹,

Hadjzadeh²,

Fatemeh³

et al. 2012

Phcog Mag

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Background:Herbal medicine is widely used in the treatment of diseases like diabetes mellitus. We investigated the effects of guar gum in diabetic rats for the reduction of the risk of diabetes and cardiovascular disease. Dietary pattern emphasizing foods high in complex carbohydrates and fiber are associated with low blood glucose and cholesterol levels.Materials and Methods:Diet containing 0%, 5%, 10% and 20% (w/w) guar gum was fed to diabetic rats for 28 days. Blood serum glucose, triglycerides, cholesterol, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol levels, atherogenic index levels, body weights and food intake were monitored at 0, 7.14 and 28 days after induction of diabetes.Results:In spite of the fact that diabetes elevated blood lipids in all rats after 14 days, the guar gum diet significantly decreased the serum concentration of cholesterol, triacylglicerols and LDL-C and atherogenic index. The most significant result in this study was the reduction of blood glucose in diabetic rats treated with the guar gum diet after 28 days versus non- and glibenclamide-treated rats. The gum promoted a general improvement in the condition of the diabetic rats in body weight and food intake in comparison with nontreated rats.Conclusion:The results of this research suggest that guar gum was significantly effective in comparison with glibenclamide in the treatment of hyperlipidemia and hyperglycemia in diabetes rats. Therefore, it may be suggested as a reliable fiber in diabetic regimes in diabetic patients.

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Structure–antioxidant relationships of sulfated galactomannan from guar gum

Cited by 73 publications

References 35 publications

In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

In vitro assessment of anti-HCV, antioxidant, cytotoxic and hypolipidemic activities of glycoprotein isolated from Spirulina platensis

Characterization and cytotoxic activity of sulfated derivatives of polysaccharides from Agaricus brasiliensis

Antihyperglycemic and antihyperlipidemic effects of guar gum on streptozotocin-induced diabetes in male rats

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