STRUCTURE AND SYNTHESIS OF KINETIN<sup>1</sup>

Miller, Carlos O.; Skoog, Folke; Okumura, Francis Shigeo; Saltza, M. H. von; Strong, F. M.

doi:10.1021/ja01614a108

Cited by 198 publications

(53 citation statements)

References 4 publications

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“…tRNA-free cytokinins are present in plants where they act as phytohormones to promote and regulate several growth and developmental processes (Miller et al, 1955;Mok, 1994). Cytokinins in their tRNA-bound form are found in several organisms, including mammals (Persson et al, 1994) and represent one of the numerous post-transcriptional modifications of tRNA molecules.…”

Section: Introductionmentioning

confidence: 99%

Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer

et al. 2005

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Section: Introductionmentioning

confidence: 99%

Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer

et al. 2005

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“…The family of plant hormones known as cytokinins were discovered by their ability to induce cell division in cell cultures (1,2). Naturally occurring cytokinins are adenine derivatives and, dependent on the nature of the N 6 -side chain, are classified into isoprenoid or aromatic cytokinins (3).…”

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confidence: 99%

N-Glucosylation of Cytokinins by Glycosyltransferases of Arabidopsis thaliana

Hou

Lim

Higgins

et al. 2004

Journal of Biological Chemistry

273

218

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Cytokinins are plant hormones that can be glucosylated to form O-glucosides and N-glucosides. The glycoconjugates are inactive and are thought to play a role in homeostasis of the hormones. Although O-glucosyltransferases have been identified that recognize cytokinins, the enzymes involved in N-glucosylation have not been identified even though the process has been recognized for many years. This study utilizes a screening strategy in which 105 recombinant glycosyltransferases (UGTs) of Arabidopsis have been analyzed for catalytic activity toward the classical cytokinins: trans-zeatin, dihydrozeatin, N 6 -benzyladenine, N 6 -isopentenyladenine, and kinetin. Five UGTs were identified in the screen. UGT76C1 and UGT76C2 recognized all cytokinins and glucosylated the hormones at the N 7 and N 9 positions. UGT85A1, UGT73C5, and UGT73C1 recognized trans-zeatin and dihydrozeatin, which have an available hydroxyl group for glucosylation and formed the O-glucosides. The biochemical characteristics of the N-glucosyltransferases were analyzed, and highly effective inhibitors of their activities were identified. Constitutive overexpression of UGT76C1 in transgenic Arabidopsis confirmed that the recombinant enzyme functioned in vivo to glucosylate cytokinin applied to the plant. The role of the N-glucosyltransferases in cytokinin metabolism is discussed.

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“…Kinetin (6-furfurylaminopurine) has been shown to increase the rate of cell division in tobacco wound callus tissue when used in conjunction with 2 ,ugm/ml of indoleacetic acid (IAA) (2,3). The present experiments were undertaken to determine the effect of kinetin on the responses of fragments of sunflower hvpocotvl to IAA previously described (1).…”

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confidence: 99%

Kinetin and Auxin Activity

Deropp¹

1956

Plant Physiol.

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STRUCTURE AND SYNTHESIS OF KINETIN¹

Cited by 198 publications

References 4 publications

Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer

Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer

N-Glucosylation of Cytokinins by Glycosyltransferases of Arabidopsis thaliana

Kinetin and Auxin Activity

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STRUCTURE AND SYNTHESIS OF KINETIN1

Cited by 198 publications

References 4 publications

Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer

Identification and functional characterization of the candidate tumor suppressor gene TRIT1 in human lung cancer

N-Glucosylation of Cytokinins by Glycosyltransferases of Arabidopsis thaliana

Kinetin and Auxin Activity

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Product

Resources

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STRUCTURE AND SYNTHESIS OF KINETIN¹