Structure and stability of cyclodextrin inclusion complexes with the ferrocenium cation in aqueous solution: 1H NMR studies

Moozyckine, Alexei U.; Bookham, Jonathan L.; Deary, Michael E.; Davies, D. Martin

doi:10.1039/b008440i

Cited by 43 publications

(33 citation statements)

References 26 publications

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“…Figure 2b shows the dependence of the optical responses obtained in Fig. 2a with the reported stability constants for cyclodextrin/ferrocene [19] and cyclodextrin/adamantanecarboxylic acid [20] systems. As can be seen, there is a direct relationship between the stability of the inclusion complex and the optical response obtained, clearly demonstrating that the immobilisation of the polymeric carrier on the surface takes place through inclusion complexation.…”

Section: Resultsmentioning

confidence: 85%

“…These plates are fabricated with cheap polymeric materials such as polystyrene allow high throughput genomic and proteomic analysis for many biomedical research and clinical diagnostics applications. In this paper we describe the development of an ELONA-type assay for the detection of a human leukocyte antigen (HLA) allele associated with celiac disease [18], an autoimmune condition of known genetic predisposition [19]. The surface of maleimide-pre-coated microtitre plates was modified with a layer of thiolated cyclodextrin polymer and used for the supramolecular capture of adamantane (ADA) or ferrocene (Fc)-modified carboxymethylcellulose (CMC) polymers bearing DNA probes (Scheme 1).…”

Section: Introductionmentioning

confidence: 99%

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Highly sensitive colorimetric enzyme-linked oligonucleotide assay based on cyclodextrin-modified polymeric surfaces

et al. 2012

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In this paper, we describe the development of an enzyme-linked oligonucleotide assay for the detection of a human leukocyte antigen allele associated with celiac disease based on cyclodextrin-modified polymeric surfaces. The surface of maleimide-pre-coated plates was modified with a layer of thiolated cyclodextrin polymer and used for the supramolecular capture of adamantane or ferrocene-modified carboxymethylcellulose polymers bearing DNA probes. The assay was optimised in terms of incubation time, temperature, and surface chemistry and applied to the highly sensitive and selective detection of HLA sequences with a limit of detection of 0.7 nM. A real sample analysed using this platform showed an excellent correlation with maleimide-activated plates using thiolated DNA probes.

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Section: Resultsmentioning

confidence: 85%

Section: Introductionmentioning

confidence: 99%

Highly sensitive colorimetric enzyme-linked oligonucleotide assay based on cyclodextrin-modified polymeric surfaces

et al. 2012

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“…The authors utilized the redox-responsive host-guest interaction to induce a sol-gel phase transition of the hydrogel. β-CD has a high affinity for the neutral Fc; however, the complex rapidly dissociates when Fc is oxidized (Fc + ) [232]. The self-healing properties were also investigated.…”

Section: Self-healing Polymers Based On Reversible Host-guest Interacmentioning

confidence: 99%

Intrinsic Self-Healing Polymers Based on Supramolecular Interactions: State of the Art and Future Directions

Enke

Döhler

Bode

et al. 2015

Self-Healing Materials

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Supramolecular polymers are an intriguing class of materials with dynamic behavior as a result of the presence of non-covalent bonds. These bonds include hydrogen bonds, metallopolymers, ionomers, host-guest as well as π-π interactions. The strength of these supramolecular bonds can be tuned by varying the binding motifs. Their reversible and dynamic character can be utilized to engineer self-healing polymers. This review briefly presents the preconditions for design of self-healing polymers and summarizes the development of supramolecular self-healing polymers based on various non-covalent interactions. Furthermore, challenges and perspectives for the understanding of self-healing mechanisms and the preparation of novel materials with enhanced properties are discussed.

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“…[4] In addition to this, the one-electron oxidation of the ferrocene derivatives provides a reversible mechanism to release the CD receptors from these supramolecular complexes, as it is well known that the binding affinity of a ferrocene-βCD inclusion complex decreases by approximately two orders of magnitude upon oxidation of the ferrocene guest, effectively going from a K value in the range 1 ϫ 10 3 to 5 ϫ 10 3  -1 to less than 50  -1 . [5] Our joint work with the Madrid group quickly moved to the exploration of the binding interactions between a similar series of dendrimers containing multiple cobaltocenium units on their surfaces and cyclodextrin hosts. [6] The simplest structures (dendrimers 5 and 6) within this dendrimer series are shown in Figure 3.…”

Section: Dendrimers Containing Multiple Peripheral Metallocene Residuesmentioning

confidence: 99%

Electron Transfer and Molecular Recognition in Metallocene‐Containing Dendrimers

Kaifer

2007

Eur J Inorg Chem

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This manuscript provides a summary of the relatively large body of research on the preparation and characterization of dendrimers containing (1) multiple copies of metallocene residues on their surfaces or (2) a single metallocene residue at their core. Special emphasis is placed on dendrimers functionalized with either ferrocene or cobaltocenium groups, because their reversible electrochemistry makes them particularly attractive to the author's group. Dendrimers containing multiple, peripheral metallocene residues are of interest to develop multivalent interactions with suitable receptors or receptor assemblies. With dendrimers containing a single metallocene at their cores, the key questions relate to the effects of the dendritic mass on their properties and degree of encapsulation or site isolation. We focused our work on the electrochemical properties of these dendrimers as well as on their use as guests in molecular recognition processes with freely diffusing hosts.(© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)

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Structure and stability of cyclodextrin inclusion complexes with the ferrocenium cation in aqueous solution: 1H NMR studies

Cited by 43 publications

References 26 publications

Highly sensitive colorimetric enzyme-linked oligonucleotide assay based on cyclodextrin-modified polymeric surfaces

Highly sensitive colorimetric enzyme-linked oligonucleotide assay based on cyclodextrin-modified polymeric surfaces

Intrinsic Self-Healing Polymers Based on Supramolecular Interactions: State of the Art and Future Directions

Electron Transfer and Molecular Recognition in Metallocene‐Containing Dendrimers

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