Structure and Reactivity of a Dinuclear Cobalt(III) Complex with a Bridging Phosphate Monoester

Spectroscopic and mechanistic studies of dinuclear metallohydrolases and their biomimetic complexes

“…Since Sargeson's early work other examples of functional or spectroscopic model complexes for several dicobalt(III)/(II) complexes have been reported. 149,[176][177][178][179][180][181][182][183][184][185] For the Co(II) complexes in the present studies the activity towards organophosphoesters using BDNPP, was investigated (Table 2). 136 All complexes are good functional mimics for phosphodiesterases and show one pK a relevant for hydrolysis.…”

Dinuclear macrocyclic polyamine zinc(II) complexes: Syntheses, characterization and their interaction with plasmid DNA

“…Bimetallic complexes, having both metals available to coordinate to the DNA, may bind much more tightly than 2 equiv of corresponding monometallic complexes through a concerted two-point binding-to-DNA mechanism [15,16,20]. Scheme 2 shows a supposed mechanism according to the X-ray structures of the complexes and some reports from literatures [47,48]. In this catalytic cycle, the dinuclear complexes I firstly combine with DNA to form intermediate II via a synergistic effect between the two zinc ions, and the two metal ions can activate the central phosphorus atom.…”

Structure, Equilibrium and Ribonuclease Activity of Copper(II) and Zinc(II) Complexes Formed with a Dinucleating Bis-Imidazole Ligand

“…Due to the constant ratio of the protonation isomers, no experimental data are available for their individual activity. An overview of the literature data indicates, however, higher hydrolytic activity of rigidly pre-organised bimetallic cores, [2,29] allowing direct metal-metal cooperation, as compared with the more flexible dinuclear complexes. This would suggest the predominance of the Zn 2 (L Ϫ1H )(OH) isomer in the hydrolytic processes.…”