Structure and properties ofn-alkyldimethylsilyl bonded silica reversed-phase packings

Roumeliotis, P.; Unger, Klaus K.

doi:10.1016/s0021-9673(00)80987-5

Cited by 187 publications

(41 citation statements)

References 13 publications

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“…A similar conclusion was drawn in earlier pubications from this (2,3) and other ( 4 ) laboratories. Although hydrolysis and dissolution are rather slow processes in LC practice, the RP-HPLC phase deteriorates after a period of intensive use.…”

Section: Introductionsupporting

confidence: 90%

Influence of alkyl chain length on the stability of n-alkyl-modified reversed phases. 1. Chromatographic and physical analysis

Hetem¹,

Haan²,

Claessens³

et al. 1990

Anal. Chem.

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Document VersionPublisher's PDF, also known as Version of Record (includes final page, issue and volume numbers) Please check the document version of this publication:• A submitted manuscript is the author's version of the article upon submission and before peer-review. There can be important differences between the submitted version and the official published version of record. People interested in the research are advised to contact the author for the final version of the publication, or visit the DOI to the publisher's website.• The final author version and the galley proof are versions of the publication after peer review.• The final published version features the final layout of the paper including the volume, issue and page numbers. General rights Copyright and moral rights for the publications made accessible in the public portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognise and abide by the legal requirements associated with these rights. Link to publication• Users may download and print one copy of any publication from the public portal for the purpose of private study or research.• You may not further distribute the material or use it for any profit-making activity or commercial gain • You may freely distribute the URL identifying the publication in the public portal ? Take down policyIf you believe that this document breaches copyright please contact us providing details, and we will remove access to the work immediately and investigate your claim. Several factor$ affecting long-term stability of modern reversed-phase htgh-performance llquld chromatography (RP-HPLC) phases are consldered and their lndlvldual contrlbutlons are evaluated In this paper and the following paper In this Issue. Tho stationary phases under study were Identically modifled on the same batch of slllca substrate to ellmlnate dmerences In substrate properties and synthesis conditions. Modtflcatlons with llgand alkyl chain length between C1 and C18 were performed such that an approxknately equal llgand density was obtained for the seven RP-HPLC phases studled. These n-alkyldimethyldloxydlane bonded phases were exposed to sknulated aglng experlments. A subsequent chromatographk characterlzatlon regarding changes In capacity, llp6phlUc and polar sdectlvlty, and slllca degradatlon related separation performance was carried out.

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Section: Introductionsupporting

confidence: 90%

Influence of alkyl chain length on the stability of n-alkyl-modified reversed phases. 1. Chromatographic and physical analysis

Hetem¹,

Haan²,

Claessens³

et al. 1990

Anal. Chem.

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“…Stober [644] noticed already that not more than 2.5 trimethylsilyl groups per nm 2 could be grafted to the surface of Aerosil silica. Similar results corresponding to a binding of 4.0 /lmol m -2 were reported by Kiselev et al [645] and by Unger et al [646,647]. This implies that only approximately half of the silanol groups on the surface can react with CISiMe 3 .…”

supporting

confidence: 86%

“…The surface area of a fine particle size silica will be significantly changed by the binding of a layer of a thickness which is not insignificant with respect to the particle radii [621,647]. Obviously, the pore structure of mesoor microporous substances will be influenced, too [647].…”

mentioning

confidence: 99%

Nature and Estimation of Functional Groups on Solid Surfaces

Boehm

Knözinger

1983

Catalysis

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“…Generally, tri-and dichlorosilanes are used. The stoichiometry of these reactions has been studied extensively [11,12].…”

Section: Alkylsilane Modified Supportsmentioning

confidence: 99%

“…The surface hydroxyl group concentration was found to be 8 #mole m -2. Therefore the statement "... use a fully hydroxylated silica with the highest population of hydroxyl groups as possible ..." to achieve a dense monolayer of bonded molecules [11 ], is a dubious one. A study of the effect of partial dehydration of the silica surface prior to silanization seems worthwhile.…”

Section: Alkylsilane Modified Supportsmentioning

confidence: 99%

Synthesis of a nonpolar, chemically bonded stationary phase with low residual hydroxyl group content

et al. 1980

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Structure and properties ofn-alkyldimethylsilyl bonded silica reversed-phase packings

Cited by 187 publications

References 13 publications

Influence of alkyl chain length on the stability of n-alkyl-modified reversed phases. 1. Chromatographic and physical analysis

Influence of alkyl chain length on the stability of n-alkyl-modified reversed phases. 1. Chromatographic and physical analysis

Nature and Estimation of Functional Groups on Solid Surfaces

Synthesis of a nonpolar, chemically bonded stationary phase with low residual hydroxyl group content

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