Structure and properties of titanium oxide layers prepared by metal plasma immersion ion implantation and deposition

Tsyganov, I. A.; Maitz, Manfred F.; Wieser, E.; Prokert, F.; Richter, E.; Rogozin, A.I.

doi:10.1016/s0257-8972(03)00687-x

Cited by 35 publications

(30 citation statements)

References 11 publications

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“…Titanium oxides are known to be good hemocompatible; therefore they are suggested as coating for blood contacting implants. Studies of blood plasma protein interactions with titanium oxides are a possible way to understand the interaction of foreign surfaces with blood better and also their integration in tissue, since blood is the first medium encountered during the surgical procedure and thus governs the subsequent cell attachment and wound healing [17,18]. Based on repetitive oxidationreduction processes can be concluded that the created amount of TiO 3 inside of the TiO 2 surface layer seems to be constant [19].…”

Section: Introductionmentioning

confidence: 99%

Oxidative stress and antioxidant responses of liver and kidney tissue after implantation of titanium or titanium oxide coated plate in rat tibiae

El-Shenawy

Mohsen

Fadlallah

2012

J Mater Sci: Mater Med

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Coating with titanium oxides is a promising method to improve the blood compatibility of materials to be used for medical implants. However, biodegradation of the coating can result in microparticles that subsequently cause oxidative stress. Therefore, the present study was carried out to throw some light on the mechanisms affecting the reaction of tissue surroundings Ti implants either in the form of titanium oxide or not in tibiae of rats. The serum collected twice from animals during the period of study and rats were sacrificed after two months of implantation. The complete blood picture, total proteins content and the activities of some serum enzymes were determined as liver biomarker. Kidney function was examined by measuring the levels of serum creatinine and uric acid. The level of lipid peroxidation and the activities of superoxide dismutase, catalase and glutathione S-transferase as well as glutathione content in liver and kidney tissue were evaluated. It has been indicated that the lipid peroxidation is one of the molecular mechanisms involved in Ti-plate induced cytotoxicity however; the TiO(2)-plate did not. The biodegradation of Ti-plate was very slow that could explain why the all enzymatic and non-enzymatic antioxidant not affected by implantation of Ti-plate. The total antioxidant level in serum was better in rats had TiO(2)/Ti-plate than those animals that had Ti-plate. The coating of titanium implants with titanium oxide leads to attaining of reduced the oxidative state in the cells, which enhance the healing process in comparison with the uncoated implants.

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Section: Introductionmentioning

confidence: 99%

Oxidative stress and antioxidant responses of liver and kidney tissue after implantation of titanium or titanium oxide coated plate in rat tibiae

El-Shenawy

Mohsen

Fadlallah

2012

J Mater Sci: Mater Med

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“…The biomedical effects of titanium oxides can be studied by starting with the titanium base metal and use oxygen plasma treatment [205,206], or one may produce titanium oxide, or related compound layers, like oxynitrides, using a vacuum arc [207,208,209]. It is known that titanium dioxide exists in amorphous and three different crystalline phases: anatase, rutile, and brookite; anatase and rutile are the more common ones, and the latter is usually produced when the substrate is at elevated temperature.…”

Section: Titanium-based Materialsmentioning

confidence: 99%

“…Tsyganov and colleagues at Rossendorf [209] showed that amorphous, nanocrystalline, and fine-grained layers show somewhat higher blood clotting times than well-crystallized rutile films. Implantation of Cr or P ions reduced the clot formation, and P-implanted surfaces show additionally improved platelet adherence.…”

Section: Titanium-based Materialsmentioning

confidence: 99%

Some Applications of Cathodic Arc Coatings

Anders

2008

Cathodic Arcs

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“…[1][2][3][4][5] Among the three well known crystallographic structures (anatase, rutile, and brookite) of titanium dioxide, only anatase and rutile are applied commercially and commonly. 6 Meanwhile, TiO 2 anatase has been suggested to exert a greater toxic effect than TiO 2 rutile. 7,8 It is possible for industrial or commercial TNPs to spread into the air of indoor or outdoor atmosphere during the process of production, use, distribution, and recycle.…”

Section: Introductionmentioning

confidence: 99%

“…Bai et al Afterwards, 5×10 6 transducing units of lentivirus with 500 μL of enhanced infection solution and polybrene (5 μg/mL) were mixed to infect BEAS-2B cells at 70% confluence according to the manufacturer's instructions (Genechem).…”

mentioning

confidence: 99%

Downregulation of B-cell lymphoma/leukemia-2 by overexpressed microRNA 34a enhanced titanium dioxide nanoparticle-induced autophagy in BEAS-2B cells

Bai¹,

Chen²,

Sun³

et al. 2016

IJN

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Titanium dioxide (TiO 2 ) nanoparticles (TNPs) are manufactured worldwide for a wide range of applications and the toxic effect of TNPs on biological systems is gaining attention. Autophagy is recognized as an emerging toxicity mechanism triggered by nanomaterials. MicroRNA 34a (miR34a) acts as a tumor suppressor gene by targeting many oncogenes, but how it affects autophagy induced by TNPs is not completely understood. Here, we observed the activation of TNP-induced autophagy through monodansylcadaverine staining and LC3-I/LC3-II conversion. Meanwhile, the transmission electron microscope ultrastructural analysis showed typical morphological characteristics in autophagy process. We detected the expression of miR34a and B-cell lymphoma/leukemia-2 (Bcl-2). In addition, the underlying mechanism of TNP-induced autophagy was performed using overexpression of miR34a by lentivirus vector transfection. Results showed that TNPs induced autophagy generation evidently. Typical morphological changes in the process of autophagy were observed by the transmission electron microscope ultrastructural analysis and LC3-I/LC3-II conversion increased significantly in TNP-treated cells. Meanwhile, TNPs induced the downregulation of miR34a and increased the expression of Bcl-2. Furthermore, overexpressed miR34a decreased the expression of Bcl-2 both in messenger RNA and protein level, following which the level of autophagy and cell death rate increased after the transfected cells were incubated with TNPs for 24 hours. These findings provide the first evidence that overexpressed miR34a enhanced TNP-induced autophagy and cell death through targeted downregulation of Bcl-2 in BEAS-2B cells.

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Structure and properties of titanium oxide layers prepared by metal plasma immersion ion implantation and deposition

Cited by 35 publications

References 11 publications

Oxidative stress and antioxidant responses of liver and kidney tissue after implantation of titanium or titanium oxide coated plate in rat tibiae

Oxidative stress and antioxidant responses of liver and kidney tissue after implantation of titanium or titanium oxide coated plate in rat tibiae

Some Applications of Cathodic Arc Coatings

Downregulation of B-cell lymphoma/leukemia-2 by overexpressed microRNA 34a enhanced titanium dioxide nanoparticle-induced autophagy in BEAS-2B cells

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