Structure and properties of model membranes: new knowledge from high-pressure vibrational spectroscopy

Wong, P. T. T.; Siminovitch, D.; Mantsch, Henry H.

doi:10.1016/0304-4157(88)90023-8

Cited by 153 publications

(89 citation statements)

References 136 publications

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“…Table 2) is comparable to previous studies for the transition temperature. The value for the proportionality factor, γ, averaged over various literature values yields a mean value γ j ) 7.34‚10 -4 mL/J for DMPC MLV, 12,14,16,20,21 γ j ) 7.07‚10 -4 mL/J for DPPC MLV, 14,16,[19][20][21]39,40 and γ j ) 7.63‚10 -4 mL/J for distearoyl phosphatidylcholine MLV. 13,20 Similar numbers where found for dieladioyl phoshatidylcholine and palmitoyl oleoyl phosphatidylcholine.…”

Section: Discussionmentioning

confidence: 99%

“…The pressure dependence of the melting transition has been investigated before by various authors. 12,13,16,[18][19][20][21]36,37 It has been shown that the shift of the lipid melting transition is linear with the applied hydrostatic pressure in a pressure range up to at least 2 kbar. However, these authors were mainly interested in the shift of the transition point.…”

Section: Discussionmentioning

confidence: 99%

“…3,4 This paper is mainly focused on the changes in lipid volume during a chain melting transition. The volumetric properties of lipids have been extensively studied by many methods, for example by densitometry or dilatometry 2,[5][6][7][8][9][10][11][12] and by investigation of the effect of pressure on light scattering or transmission, [13][14][15] spectral changes, [16][17][18] heat capacities, 19 X-ray or neutron scattering, [20][21][22][23] and other methods. Anthony et al 10 found that the volume expansion coefficient of single lipid membranes has a very similar temperature dependence as the heat capacity.…”

Section: Introductionmentioning

confidence: 99%

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Enthalpy and Volume Changes in Lipid Membranes. I. The Proportionality of Heat and Volume Changes in the Lipid Melting Transition and Its Implication for the Elastic Constants

2001

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Differential scanning calorimetry, pressure calorimetry, and densitometry have been employed to study the relation between volume and enthalpy changes in the melting regime of lipid membranes. We demonstrate a rigid proportional relation between volume expansion coefficient and heat capacity. This result is first shown in densitometric experiments. It implies that calorimetric profiles obey a simple scaling law for the temperature axes in experiments with applied hydrostatic pressure. In a theoretical paper (Heimburg, T. Biochim. Biophys. Acta 1998, 1415, 147-162), we have argued that this relation has far-reaching consequences for the predictiblity of elastic constants from the heat capacity. The proportionality constant between volume and enthalpy changes is found to be independent of the lipid, which has interesting consequences for the calculation of the elastic constants of biological lipid mixtures with unknown composition. We demonstrate this for lung surfactant, which displays a similar relation between volume and enthalpy changes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enthalpy and Volume Changes in Lipid Membranes. I. The Proportionality of Heat and Volume Changes in the Lipid Melting Transition and Its Implication for the Elastic Constants

2001

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“…In addition, the peak position of the N-H stretching mode was found to shift to a lower wavenumber at the center of the Hertzian contact region, as shown in Figure 6. The peak position of the C-H stretching mode related to hydrocarbon oil is known to shift to higher wavenumbers at higher pressures [11][12][13]. The peak shifts to lower wavenumbers as the applied load is increased.…”

Section: Resultsmentioning

confidence: 99%

<i>In Situ</i> Observation of Lubricant Film of Semi-Solid Lubricants at EHL Contact Using Micro-FTIR

et al. 2016

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Semi-solid lubricants, such as grease and gels, are mixtures of oil, thickeners, and gel agents. In this study, the concentration of the urea thickener and gel agent at the point of elastohydrodynamic lubrication (EHL) contact was investigated by in situ observation with a micro-Fourier transform infrared spectrometer (micro-FTIR). Micro-FTIR was used in conjunction with a ball-on-disk lubrication tester. The lubricant film was analyzed by micro-FTIR under dynamic conditions. Characteristic peaks correlating to the C-H stretching mode at 2850-3000 cm -1 and the N-H stretching mode at 3000-3500 cm -1 were found to originate from the oil and the urea thickener and gel agent, respectively. The concentration of the thickener and gel agent were estimated from these characteristic IR peaks. The results showed that the concentration of urea thickener and gel agent was increased drastically at the Hertzian contact region. Meanwhile, infrared spectra under hydrostatic pressure were obtained using a diamond-anvil cell. It was confirmed that the hydrogen bonding of the urea thickener and gel agent was stabilized under high-pressure conditions.

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“…Another group at NRC used high-pressure infrared and Raman spectroscopy to look into the various types of ice (an appropriate subject for Canada), so when Patrick Wong a member of that group transferred to our lab in 1980 he brought along a new tool for probing order-disorder transitions in biological systems. This allowed us to explore lipid polymorphism by inducing phase transitions through an increase in pressure as opposed to the conventional way of decreasing the temperature [35].…”

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confidence: 99%

The evolution of biomedical vibrational spectroscopy: A personal perspective

Mantsch

2015

BSI

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PreambleWhen my colleague Parvez Haris asked me to write a historical review on the evolution of biomedical vibrational spectroscopy I consented, but now I need to clarify what this review is about and what it is not. It is my personal belief that biomedical vibrational spectroscopy has yet to reach its full potential and therefore I will not restrict myself to recounting its past history but will look ahead to its future and where it may still be evolving. Accordingly, my review will comprise two parts. As yours truly has now joined the league of octogenarians, in the first part I plan to share with the readers my personal recollections of the very early days of vibrational bio-spectroscopy which I was privileged to witness and be part of. In the second part I intend to peer into the crystal ball and speculate on new applications in the medical sciences, envisioning vibrational spectroscopy as a tool for the exploration of the human mind to probe psychosomatic diseases and emotional disorders. The arduous road to biomedical vibrational spectroscopy: Where did we come from?As is often the case with historical reviews it can be difficult to precisely pinpoint a beginning since this depends on how far back the reviewer is prepared to go. The exploitation of vibrational spectroscopy for use in medicine clearly relies on earlier applications in biology, which go back to previous uses in chemistry, which in turn rest on the solid foundations of vibrational spectroscopy in physics. Having said this I now wish to refer the reader to a few reviews which deal with this progression of vibrational spectroscopy from physics to chemistry to biology to medicine. Four pre-eminent publications, written in 1985Four pre-eminent publications, written in [14], 2009Four pre-eminent publications, written in [1], 2012Four pre-eminent publications, written in [11] and 2014 supply over 700 bibliographic references (with some duplications) that comprehensively document this evolution, allowing this reviewer to focus on events he has personally witnessed and experienced over the past 50+ years.It is fair to state that until the 1950s vibrational spectroscopy was the purview of physics, when a growing number of chemists began to employ it regularly for the elucidation of molecular structures.

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Structure and properties of model membranes: new knowledge from high-pressure vibrational spectroscopy

Cited by 153 publications

References 136 publications

Enthalpy and Volume Changes in Lipid Membranes. I. The Proportionality of Heat and Volume Changes in the Lipid Melting Transition and Its Implication for the Elastic Constants

Enthalpy and Volume Changes in Lipid Membranes. I. The Proportionality of Heat and Volume Changes in the Lipid Melting Transition and Its Implication for the Elastic Constants

<i>In Situ</i> Observation of Lubricant Film of Semi-Solid Lubricants at EHL Contact Using Micro-FTIR

The evolution of biomedical vibrational spectroscopy: A personal perspective

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