Structure and origin of intestinal pigment in cases of melanosis coli

Vogel, Alexander; W, Fabricius; Dulce, Hans-Joachim; Stolpmann, H. J.

doi:10.1007/bf00548469

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Melanosis Coli1

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1972

1993

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Cited by 6 publications

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“…Melanosis was observed in 12-31% of unselected constipated patients [9,10]. The morphological basis of melanosis is pig ment within the macrophages of the colonic mucosa [11], The underlying pigment is prob ably lipofuscin, but has not been character ized exactly [12,13], Therefore, 'pseudomela nosis' or 'pseudofuscinosis' have been pro posed instead o f 'melanosis' and 'lipofuscino sis', respectively. However, these terms are not more accurate but clumsier.…”

Section: Melanosis Colimentioning

confidence: 99%

Adverse Effects of Laxatives: Fact and Fiction

Müller-Lissner¹

1993

Pharmacology

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Laxatives are generally well tolerated and may be considered safe drugs. When taken at much higher than the recommended doses (laxative abuse) some side effects may occur (e.g. hypokalemia, metabolic alkalosis, renal tubular damage). It is controversial whether the laxatives currently used may lead to morphologic changes of the autonomous nervous system of the colon. Melanosis coli is due to pigment-laden macrophages within the submucosa. It occurs after long-term intake of anthraquinones and has no functional consequences. No case of ‘cathartic colon’ has been observed during the last few decades, and we can assume that it was probably caused by laxatives which are no longer in use.

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Section: Melanosis Colimentioning

confidence: 99%