1998
DOI: 10.1039/a800902c
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Structure and molecular interactions of anti-thyroid drugs. Part 2. Electron donor properties of carbimazole 1

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Cited by 23 publications
(4 citation statements)
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“…No crystal structure of their I 2 adducts was reported, however. [9,41] These authors [9,41] concluded that the action of the anti-thyroidal drugs involved diiodine sponges trapping I 2 , I ϩ or HOI [42] which were produced during the oxidation of iodide ions taken up by the thyroid. Thus, the agents should be able to form stable complexes with diiodine, diverting iodides from their second oxidation step (I 2 Ǟ 2 I ϩ ϩ 2 e Ϫ ) and in this way prevent the electrophilic substitution of I ϩ on the tyrosine residue of thyroglobulin.…”
Section: Discussionmentioning
confidence: 99%
“…No crystal structure of their I 2 adducts was reported, however. [9,41] These authors [9,41] concluded that the action of the anti-thyroidal drugs involved diiodine sponges trapping I 2 , I ϩ or HOI [42] which were produced during the oxidation of iodide ions taken up by the thyroid. Thus, the agents should be able to form stable complexes with diiodine, diverting iodides from their second oxidation step (I 2 Ǟ 2 I ϩ ϩ 2 e Ϫ ) and in this way prevent the electrophilic substitution of I ϩ on the tyrosine residue of thyroglobulin.…”
Section: Discussionmentioning
confidence: 99%
“…Each peak represents a hydrogen-bond site. The change in the vibrational frequency of the XH bond can be translated into a p K BHX value through family-dependent p K BHX –IR shift relationships. The family-dependent p K BHX –IR relationships correlate the change in IR vibrational frequency of the XH bond to p K BHX values for a family of HBAs and a reference HBD in 1:1 complexes. The FTIR spectroscopy method allows equilibrium concentrations of these 1:1 complexes to be measured in a certain frequency range, therefore allowing a p K BHX value to be obtained.…”
Section: Introductionmentioning
confidence: 99%
“…the thiocarbonyl group [137]. This conclusion cannot be extended to other types of carbimazole complexes.…”
Section: Scheme 13 Diiodine Basicities (As K In L Mol −1 ) Of the Vamentioning
confidence: 86%