Structure and Mechanical Properties of Actin Networks Crosslinked with Mutually Interacting Crosslinkers

Abstract

controls. Light and transmission electron microscopy reveals focal segmental glomerulosclerosis with thicker basement membranes and abnormal podocytes. Some of the mutant mice also have lens abnormalities consistent with early cataract formation. Our results show that even heterozygous mutations in the mouse Myh9 gene can reproduce human MYH9-related diseases. These mouse models should be useful in understanding the pathophysiology of human MYH9-related diseases and also in designing and developing therapeutic stratagies.