Structure and Immunological Specificity of Polysaccharides

Heidelberger, Michael

doi:10.1007/978-3-7091-7159-2_9

Cited by 11 publications

(11 citation statements)

References 116 publications

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“…The high frequency of unexpected cross-reactions is however most likely due to the widespread occurrence of (nearly) identical sugar chains rather than to in trinsic low specificity of the IgE antibod ies. Similar cross-reactivity patterns have been found with antisera to pneumococcal carbohydrates [2], Quite unexpectedly, the IgE antibodies to CCD were apparently induced in sever al patients by bee stings. Subsequent to one or several stings, a rise in both bee venom-specific IgE and buckwheat-spec ific IgE was observed.…”

supporting

confidence: 55%

Cross-Reactions between Vegetable Foods, Pollen and Bee Venom Due to IgE Antibodies to a Ubiquitous Carbohydrate Determinant

Aalberse¹,

Koshte²,

Clemens³

1981

Int Arch Allergy Immunol

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supporting

confidence: 55%

Cross-Reactions between Vegetable Foods, Pollen and Bee Venom Due to IgE Antibodies to a Ubiquitous Carbohydrate Determinant

Aalberse¹,

Koshte²,

Clemens³

1981

Int Arch Allergy Immunol

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“…Cross-precipitation was reciprocal but slight in the two antisera studied (Table I). From the little known of the chemistry of S XIX (17,20) the reaction would appear to be due to similarly linked residues of D-glucose or L-rhamnose in the capsular polysaccharides of the two types, but an unimpressively small proportion of antibody is involved.…”

Section: Resultsmentioning

confidence: 99%

Cross-Reactions of Pneumococcal Types

Heidelberger

Tyler

1964

The Journal of Experimental Medicine

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Classification of the pneumococci has been rendered difficult by the frequent discovery of atypical strains, many of which were eventually given individual type numbers. Avery (1) recorded such variants of Type II, and of these his IIA and IIB were later designated Types V and VI (2). Chemical relationships between the three serological types were clarified in a recent series of quantitative immunochemical studies (3, 4 a-4 c, 5). Similarly, an atypical Type III strain (6) soon became Type VIII (7) (9), and quantitative immunochemicat investigations (10 a-10 c).We have studied the chemistry of the capsular polysaccharides of Types VII and XVIII (11,12) and quantitative data are herewith given on the qualitatively long-known cross-reaction (2, 14 a) between these types. Types XVIII and VIII also cross-react (12), as do II and XIX (14 b), VI and XIV (4 b), and X and XIV, among others. Although the relationship of Types II and XX was discovered many years ago (13 a, 13 b, 14 a, 14 b), quantitative data on this instance of cross-reactivity are now given for the first time. In this connection, the X-XX cross-reaction, also long-known (13 a, 14 a, 14 b), was drawn into the study. The chemical basis of each cross-reaction is also discussed insofar as permitted by the present knowledge of the structures of the capsular polysaccharides, the principal determinants of pneumococcal type specificity. Perhaps the inadequacy of this present knowledge will stimulate further work in the field.

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“…The various cross-reactions have been reviewed by Heidelberger (359). Full coverage of this subject is beyond the scope of this chapter.…”

Section: Reactions With Antibodymentioning

confidence: 99%

“…In addition to these investigations into the mechanisms of precipitin reactions, much information has been obtained (primarily by Heidelberger and co-workers) on cross-reactions with antibodies formed against various glucuronic acid-containing polysaccharides (359,371).…”

Section: Reactions With Antibodymentioning

confidence: 99%

“…Usually, gums and hemicelluloses containing 4-O-methyl glucuronic acid are less reactive than those possessing nonmethylated glucuronic acid (359,366). However, in some cases, gums with 4-O-methyl glucuronic acid end groups cross-react strongly (508,512), and in no case does there seem to be complete failure of cross-reactivity between Type II antiserum and a plant polysaccharide possessing terminal 4-O-methylglucuronic acid (359,361,366).…”

Section: Reactions With Antibodymentioning

confidence: 99%

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