Structure and Function of the B Cell Antigen Receptors

Alber, Gottfried; Flaswinkel, Heinrich; Kim, K.-M.; Weiser, Peter; Reth, Michael

doi:10.1007/978-3-642-51479-1_4

Progress in Immunology Vol. VIII 1993

DOI: 10.1007/978-3-642-51479-1_4

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Structure and Function of the B Cell Antigen Receptors

Gottfried Alber

Heinrich Flaswinkel

K.-M. Kim

et al.

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2022

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Cited by 2 publications

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“…The four subunits of disulfide-linked homodimeric heavy chains of mIg and disulfide-linked heterodimeric Iga/b in the BCR complex are type I transmembrane proteins. The BCR can be divided into five major classes according to their various heavy chains (6)(7)(8).…”

mentioning

confidence: 99%

Cryo-EM structures of two human B cell receptor isotypes

Zhu

Dong

et al. 2022

Science

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The B cell receptor (BCR) complex plays a critical role in B cell development and immune responses. The assembly mechanisms underlying the BCR complex remain unknown. We determined the cryo–electron microscopy (cryo-EM) structures of human IgG-BCR and IgM-BCR, which consist of membrane-bound immunoglobulin molecules (mIg) and Igα/β subunits at a 1:1 stoichiometry. Assembly of both BCR complexes involves their extracellular domains, membrane-proximal connection peptides, and transmembrane (TM) helices. The TM helices of mIgG and mIgM share a conserved set of hydrophobic and polar interactions with Igα/β TM helices. By contrast, the IgG-Cγ3 and IgM-Cμ4 domains interact with extracellular Ig-like domains of Igα/β through head-to-tail and side-by-side modes, respectively. This work reveals the structural basis for BCR assembly and provides insights into BCR triggering.

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mentioning

confidence: 99%

Cryo-EM structures of two human B cell receptor isotypes

Zhu

Dong

et al. 2022

Science

View full text Add to dashboard Cite

show abstract

Structural principles of B cell antigen receptor assembly

Dong

Bartels-Burgahn

et al. 2022

Nature

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Structure and Function of the B Cell Antigen Receptors

Cited by 2 publications

References 21 publications

Cryo-EM structures of two human B cell receptor isotypes

Cryo-EM structures of two human B cell receptor isotypes

Structural principles of B cell antigen receptor assembly

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