Structure and Function of Serum and Membrane Immunoglobulin D (IgD)

Leslie, Gerrie A.; Martin, Louis N.

doi:10.1007/978-1-4757-0779-3_1

Cited by 22 publications

(4 citation statements)

References 6 publications

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“…Serum IgD is often increased in patients with autoimmune diseases, such as rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) (174,(198)(199)(200)(201), consistent with the observation that many mature B cells class switched to IgD are autoreactive in healthy individuals (145). Anti-nuclear IgD antibodies were found in SLE patients (145,193,(202)(203)(204)(205)(206), and a slight increase in serum IgD was found in patients with Sjögren's syndrome and in a patient with autoimmune thyroiditis (207).…”

Section: Autoimmunitymentioning

confidence: 99%

New insights into the enigma of immunoglobulin D

Chen

Cerutti

2010

Immunological Reviews

112

154

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SummaryImmunoglobulin D (IgD) has remained a mysterious antibody class for almost half a century. IgD was initially thought to be a recently evolved Ig isotype expressed only by some mammalian species, but recent discoveries in fishes and amphibians demonstrate that IgD was present in the ancestor of all jawed vertebrates and has important immunological functions. The structure of IgD has been very dynamic throughout evolution. Mammals can express IgD through alternative splicing and class switch recombination (CSR). Active cell-dependent and T-cell-independent IgM-to-IgD class switching takes place in a unique subset of human B cells from the upper aerodigestive mucosa, which provides a layer of mucosal protection by interacting with many pathogens and their virulence factors. Circulating IgD can bind to myeloid cells such as basophils and induce antimicrobial, inflammatory, and B-cell-stimulating factors upon cross-linking, which contributes to immune surveillance but also inflammation and tissue damage when this pathway is overactivated under pathological conditions. Recent research shows that IgD is an important immunomodulator that orchestrates an ancestral surveillance system at the interface between immunity and inflammation.

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Section: Autoimmunitymentioning

confidence: 99%

New insights into the enigma of immunoglobulin D

Chen

Cerutti

2010

Immunological Reviews

112

154

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“…Serum IgD was increased in patients with autoimmune diseases who also had increased IgG, IgA, and IgM (83,87,116,133,141). High values of serum IgD were found in some, but not all, adults with rheumatoid arthritis (136) and in children with juvenile rheumatoid arthritis (51).…”

Section: Immunodeficienciesmentioning

confidence: 99%

Immunoglobulin D: Properties, Measurement, and Clinical Relevance

Vladutiu

2000

Clin Diagn Lab Immunol

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“…Immunoglobulins D (IgD) and E (IgE) are present in small concentrations in normal human serum, where they constitute 0.2 and 0.004% of the total immunoglobulin. IgD [reviews: Moller, 1977;Thorbecke and Leslie, 19821 is together with IgM the major receptor antibody on B lymphocytes in human peripheral blood [Leslie and Martin, 1978;Kettman et al, 19791. This immunoglobulin is uniquely susceptible to proteolytic degradation, which may account for its short half-life in human plasma, 2.8 days.…”

Section: Introductionmentioning

confidence: 99%

Kinetics of specific IgA, IgD, IgE, IgG, and IgM antibody responses in rubella

Salonen

Hovi

Meurman

et al. 1985

Journal of Medical Virology

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Rubella-specific IgD and IgE antibodies were determined with a solid-phase enzyme immunoassay using enzyme-labeled heavy-chain specific anti-immuno-globulins, and the antibody responses in rubella infection were compared to IgM, IgA, and IgG antibodies. IgD and IgE antibodies increased rapidly after the onset of infection, remained at a high level for at least 2 months, and declined slightly by 6 months. In comparison, the IgM antibodies decreased more rapidly, whereas the IgG antibodies persisted longer at a steady level. By 6 months the mean levels of the different antibodies had declined from their maximal mean levels as follows: IgM, 52%; IgA, 42%; IgE, 35%; IgD, 29%; and IgG, 8%. Thus IgD and IgE antibodies, in spite of their known short half lives, persisted longer than IgM and IgA antibodies, which limits their diagnostic value. The IgA antibody responses were found too variable to substitute for IgM antibody determination in diagnosis of a recent rubella virus infection from a single serum specimen. Comparison of maternal and cord blood sera indicated that, in addition to IgG antibodies, rubella-specific IgD antibodies were found to cross the placenta.

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Structure and Function of Serum and Membrane Immunoglobulin D (IgD)

Cited by 22 publications

References 6 publications

New insights into the enigma of immunoglobulin D

New insights into the enigma of immunoglobulin D

Immunoglobulin D: Properties, Measurement, and Clinical Relevance

Kinetics of specific IgA, IgD, IgE, IgG, and IgM antibody responses in rubella

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