Structure and Function of Plasma Proteins

Abstract

Lipoproteins are macromolecules in which the water insoluble lipids are transported in plasma. Four main lipoprotein classes have been defined in human plasma. Each of these contains esterified and nonesterified cholesterol, phospholipid and triglyceride, though in differing and characteristic proportions. Non-esterified fatty acid (NEF A) is transported as a complex with albumin; the albumin-fatty acid complex is not, however, conventionally regarded as one of the lipoproteins. The terminology used for the classification of the lipoprotein classes depends upon the methods used for their separation; a description of the methodology is thus a prerequisite to any discussion of terminology or physiology.